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In this study, 775 individuals were divided into OP and non-OP groups. Results showed that OP was associated with elevated serum calcium levels and severer amyloid-\u03b2 (A\u03b2) pathology. Regression analysis indicated a positive correlation between serum calcium and A\u03b2 PET levels. Mediation analysis further elucidated that serum calcium involved in the OP-mediated exacerbation of A\u03b2 pathology. 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