{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:21:20Z","timestamp":1788146480032,"version":"build-2803163510"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Diagnostic Model and Mechanism of Serum Myelin-Associated miRNA in Patients with Alzheimer's Disease","award":["No. s19002"],"award-info":[{"award-number":["No. s19002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a need for more studies to validate the role of gut microbiota in Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to explore the causal association between new gut microbiota and AD using Mendelian randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using genome-wide association study (GWAS) of 473 gut microbiota species and AD in IEU Open GWAS database, independent genetic loci related to gut microbiota were extracted as instrumental variables. The inverse variance weighting method was employed as the main indicator for evaluation. The stability and reliability of the results were further verified by heterogeneity test, outlier detection, horizontal pleiotropy test and leave-one-out analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following a thorough screening process, a total of 14 intestinal microbiota were included in the final analyses. The elevated abundance of\n                      <jats:italic toggle=\"yes\">Agathobacter<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Citrobacter A<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Clostridium E sporosphaeroides<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Eubacterium R<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Megamonas funiformis<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      can reduce the risk of AD. Higher abundance of\n                      <jats:italic toggle=\"yes\">Bifidobacterium<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Holdemania massiliensis<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Hydrogenophaga<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Intestinimonas massiliensis<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Megasphaera<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Paenibacillus J<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Raoultella<\/jats:italic>\n                      could increase the risk of AD. The MR-Egger analyses at 14 \u201cgenus\u201d levels showed no horizontal pleiotropy and the p values were all more than 0.05. The leave-one-out analysis showed that results were relatively stable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study revealed a causal relationship between 14 specific gut microbiota and the risk of AD occurrence. Some bacteria are protective, while others increase the risk of AD. These findings are of clinical significance for the treatment and prevention strategies in clinical practice, and it also provides new perspectives for related research on the \u201cgut-brain axis\u201d.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261422629","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T17:37:02Z","timestamp":1770399422000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The causal association between the new gut microbiota and Alzheimer's disease: A Mendelian randomization study"],"prefix":"10.1177","volume":"10","author":[{"given":"Fengwen","family":"Lin","sequence":"first","affiliation":[{"name":"North Sichuan Medical College"},{"name":"Department of Laboratory Medicine, The Second People's Hospital of Yibin\u00b7West China Yibin Hospital, Sichuan University, Yibin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second People's Hospital of Yibin\u00b7West China Yibin Hospital, Sichuan University, Yibin, China"},{"name":"College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second People's Hospital of Yibin\u00b7West China Yibin Hospital, Sichuan University, Yibin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second People's Hospital of Yibin\u00b7West China Yibin Hospital, Sichuan University, Yibin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"North Sichuan Medical College"},{"name":"Department of Laboratory Medicine, The Second People's Hospital of Yibin\u00b7West China Yibin Hospital, Sichuan University, Yibin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second People's Hospital of Yibin\u00b7West China Yibin Hospital, Sichuan University, Yibin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second People's Hospital of Yibin\u00b7West China Yibin Hospital, Sichuan University, Yibin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7495-5460","authenticated-orcid":false,"given":"Bin","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second People's Hospital of Yibin\u00b7West China Yibin Hospital, Sichuan University, Yibin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010107"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076518"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0523"},{"key":"e_1_3_3_5_2","first-page":"198","article-title":"Research progress on the correlation between tooth loss and Alzheimer's disease","volume":"33","author":"Long R","year":"2019","unstructured":"Long R, Zheng H, Wu J, et al. 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