{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:37:58Z","timestamp":1787956678044,"version":"build-2784847793"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23AG070044"],"award-info":[{"award-number":["K23AG070044"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072931"],"award-info":[{"award-number":["P30 AG072931"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG058724"],"award-info":[{"award-number":["R01AG058724"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03-AG063222"],"award-info":[{"award-number":["R03-AG063222"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R35AG072262"],"award-info":[{"award-number":["R35AG072262"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is strong desire for the return of individual results, including biomarker testing, among participants in Alzheimer's disease and related dementias (ADRD) studies. However, it is not known whether participants accurately understand the utility, limitations, benefits and risks of biomarker disclosure, nor how they weigh these factors to inform their decision to undergo testing and learn results. Furthermore, little is known about how factors like participant race or diagnosis influence a desire to learn biomarker results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This mixed-methods study explored how clinically and racially diverse participant-care partner dyads perceive and plan to use AD biomarker testing in the context of research studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      57 participants (Age:\n                      <jats:italic toggle=\"yes\">M<\/jats:italic>\n                      \u2009=\u200974.28\u2009\u00b1\u20095.98; Race:\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200922 Black,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200935 White; Diagnosis:\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200923 with mild cognitive impairment;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200934 cognitively healthy) and care partners were recruited from AD studies wherein the participant completed amyloid-\n                      <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                      and tau positron emission tomography without receiving results. Each completed an independent interview about their perspectives on learning the participant's results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Responses suggested strong interest in learning results, driven by perceived benefits (e.g., informing treatment, lifestyle changes, and social support). Risks were rarely discussed, though some respondents cited concerns about psychological burdens of a positive result. Few nuanced differences in perceived risks or benefits were observed across race and diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The decision to learn the results of biomarker testing is motivated by highly varied perceived benefits and minimal consideration of risks. Testing should be preceded by individualized counseling that carefully reviews potential benefits and risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261429997","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:45:23Z","timestamp":1773409523000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Qualitative insights into participant and care partner perspectives on research-based Alzheimer's disease biomarker testing and disclosure"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-6356","authenticated-orcid":false,"given":"Annalise","family":"Rahman-Filipiak","sequence":"first","affiliation":[{"name":"University of Michigan"},{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Lesniak","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0500-7905","authenticated-orcid":false,"given":"Alicia","family":"Burgei","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shima","family":"Sadaghiyani","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Scott","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of Michigan"},{"name":"University of Michigan School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6632-6714","authenticated-orcid":false,"given":"Peter A.","family":"Lichtenberg","sequence":"additional","affiliation":[{"name":"University of Michigan"},{"name":"Wayne State University Institute of Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-785X","authenticated-orcid":false,"given":"Alexandru","family":"Iordan","sequence":"additional","affiliation":[{"name":"University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4942-4571","authenticated-orcid":false,"given":"Jessica","family":"Mozersky","sequence":"additional","affiliation":[{"name":"Knight Alzheimer's Disease Research Center, Washington University of St. Louis, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Hampstead","sequence":"additional","affiliation":[{"name":"University of Michigan"},{"name":"University of Michigan"},{"name":"Mental Health Service (115B), Veterans Affairs Ann Arbor Health System, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58070952"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.43"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0079-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/DNND.S228939"},{"key":"e_1_3_3_7_2","article-title":"Disclosure of preclinical Alzheimer\u2019s disease biomarker results in research and clinical settings: why, how, and what we still need to know","volume":"13","author":"Erickson CM","year":"2021","unstructured":"Erickson CM, Chin NA, Johnson SC, et al. 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