{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:25:12Z","timestamp":1773275112540,"version":"3.50.1"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100011096","name":"Philippine Council for Health Research and Development","doi-asserted-by":"publisher","award":["107-185; RGAO-2019-0486"],"award-info":[{"award-number":["107-185; RGAO-2019-0486"]}],"id":[{"id":"10.13039\/501100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Monitoring drug Efficacy through Multi-Omics Research Initiative in Alzheimer's Disease (MEMORI-AD) study aims to characterize drug response to donepezil and memantine in a Filipino cohort with late-onset Alzheimer's disease (AD). To enhance enrollment, community-based dementia screening and recruitment were conducted across barangays in Manila.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study describes the experiences and challenges in community-based recruitment for multi-omics research in vulnerable populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After coordinating with local officials for approval, recruitment targeted residents aged 65 years and above. A public health lecture on dementia was held, followed by rapid screening using the \u201c10 Warning Signs of Dementia\u201d questionnaire by the Alzheimer's Disease Association of the Philippines and the AD-8 Dementia Screening Interview. Eligible participants were invited for clinical screening, including laboratory work, neuropsychological tests, and neuroimaging. Reasons for non-consent and withdrawal were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 301 eligible participants, 42 (14.0%) were suspected of dementia and eligible for work-up. Among them, 14 (33.3%) did not consent, 15 (53.6%) initially consented but withdrew, and 13 (46.4%) completed the assessment. Only 2 patients were enrolled. The main cause for non-consent was disinterest (n\u2009=\u20098, 57.1%), followed by unavailability of a legally authorized representative (LAR) (n\u2009=\u20093, 21.4%), which was also the primary reason for withdrawal (n\u2009=\u20099, 60%).\u200b<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recruitment of vulnerable Filipinos in multi-omics research within a lower-middle income country faced significant barriers, encompassing economic, psychosocial, and health constraints, largely due to disinterest and unavailability of LAR. Further studies on family dynamics, socioeconomic, and cultural factors could offer insights to overcome these recruitment barriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration Number<\/jats:title>\n                    <jats:p>Philippine Health Research Registry ID PHRR230220-0054116; ClinicalTrials.gov ID NCT05801380.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261431318","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:15:26Z","timestamp":1773224126000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Challenges in community-based recruitment of Alzheimer's disease cases: Experience of the monitoring drug efficacy through multi-omics research initiative in Alzheimer's disease (MEMORI-AD) study"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-7362","authenticated-orcid":false,"given":"Fresthel Monica M","family":"Climacosa","sequence":"first","affiliation":[{"name":"University of the Philippines Manila"},{"name":"Department of Medical Microbiology, College of Public Health, University of the Philippines Manila, Manila, Philippines"},{"name":"University of the Philippines Manila"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric David B","family":"Ornos","sequence":"additional","affiliation":[{"name":"University of the Philippines Manila"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6317-0463","authenticated-orcid":false,"given":"Erwin Rommel S","family":"Diwa","sequence":"additional","affiliation":[{"name":"University of the Philippines 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