{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:51:00Z","timestamp":1775137860409,"version":"3.50.1"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A growing number of observational studies have suggested a potential association between heart rate variability (HRV) and dementia. However, the causal nature of this relationship remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the causal relationship between HRV and dementia using two-sample Mendelian randomization (MR) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two-sample MR analysis was conducted to examine the causal effects of HRV phenotypes, including the peak-valley respiratory sinus arrhythmia or high frequency power (pvRSA\/HF), the root mean square of the successive differences of inter beat intervals (RMSSD), and normal-to-normal inter-beat intervals (SDNN), on eight dementia phenotypes (any dementia, Alzheimer's disease [AD], early-onset AD, late-onset AD, Lewy body dementia [DLB], frontotemporal dementia [FTD], Parkinson's disease dementia [PDD], and vascular dementia [VaD]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genetically determined pvRSA\/HF was associated with an elevated risk of DLB (odds ratio [OR] 1.53; 95% CI 1.04\u20132.25;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.032) and FTD (OR 2.86; 1.06\u20137.66;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.037). There was no significant association between HRV and the increased risks of AD, PDD, VaD, or any dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study provides suggestive evidence that pvRSA\/HF has a potential causal relationship with elevated risks of DLB and FTD. These findings contribute to a better understanding of the potential role of HRV in specific dementia subtypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261431319","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:32:48Z","timestamp":1773225168000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the brain-heart axis: Mendelian randomization study on the causal relationship between heart rate variability and dementia"],"prefix":"10.1177","volume":"10","author":[{"given":"Songbiao","family":"Li","sequence":"first","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Kou","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1280-1328","authenticated-orcid":false,"given":"Jinfeng","family":"Deng","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital of Sun Yat-sen 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