{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:48:09Z","timestamp":1790182089896,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) and dementia frequently coexist in older adults, yet the impact of anticoagulation on cognitive and clinical outcomes in this population remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of anticoagulation on cognitive and clinical outcomes in patients with AF and dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 291 patients aged \u226565 years with AF and dementia, treated at a tertiary center between January 2020 and December 2024. Patients were grouped by anticoagulation status. Cognitive, functional outcomes (Mini-Mental State Examination [MMSE], Activities of Daily Living [ADL], Clinical Dementia Rating\u2013Sum of Boxes [CDR-SB]) and clinical endpoints (all-cause mortality, hospitalization, major adverse cardiovascular events, and bleeding) were assessed over a median 28-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anticoagulated patients were younger (82.8 versus 85.1 years,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01). Anticoagulation was associated with slower cognitive\/functional decline, with medium effect sizes, \u0394MMSE mean difference: 2.0 points (95% CI: \u22123.5 to \u22120.4;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.048), \u0394ADL mean difference: 10.9 points (95% CI: \u221219.6 to \u22122.3;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02), \u0394CDR-SB mean difference: \u22121.4 points (95% CI: 0.4 to 2.4;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01). In multivariable Cox models, anticoagulation reduced hospitalization risk (HR 0.60; 95% CI: 0.43\u20130.84;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and all-cause mortality (HR 0.59; 95% CI: 0.40\u20130.88;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01). Benefits were most pronounced in very mild dementia and Alzheimer's disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective, confounder-adjusted study, anticoagulation was associated with slower cognitive\/functional decline and lower hospitalization\/mortality risk in AF and dementia patients. The findings warrant prospective research to investigate whether anticoagulation has disease-modifying effects in early-stage dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261433532","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:47:54Z","timestamp":1774280874000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of anticoagulation on cognitive decline and clinical outcomes in patients with atrial fibrillation and dementia: A retrospective cohort study"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6474-9891","authenticated-orcid":false,"given":"Yun","family":"Du","sequence":"first","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0288-2882","authenticated-orcid":false,"given":"Weng-Chio","family":"Tam","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-3613","authenticated-orcid":false,"given":"Man-Fong","family":"Chu","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sio-Mui","family":"Wong","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2422-0304","authenticated-orcid":false,"given":"Kuok-Wun","family":"Lam","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5646-9275","authenticated-orcid":false,"given":"Tat-Kuong","family":"Tong","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hong","family":"Wong","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chon-Hou","family":"Chan","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weng-Hong","family":"Pun","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9837-2933","authenticated-orcid":false,"given":"Mario","family":"Evora","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U-Po","family":"Lam","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Conde S\u00e3o Janu\u00e1rio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-3728","authenticated-orcid":false,"given":"Iek-Long","family":"Lo","sequence":"additional","affiliation":[{"name":"Health Bureau, The Government of Macau SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2024.01.010"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/25424823251370646"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.077"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-5-201303050-00007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01165-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx579"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.08.013"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13082418"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12781"},{"key":"e_1_3_3_11_2","article-title":"Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia","volume":"7","author":"Kwan J","year":"2022","unstructured":"Kwan J, Hafdi M, Chiang LLW, et al. 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