{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:22:09Z","timestamp":1773469329007,"version":"3.50.1"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Suzhou major clinical diseases diagnosis and treatment technology special","award":["LCZX202121"],"award-info":[{"award-number":["LCZX202121"]}]},{"name":"Research Project on Social Development Technological Innovation of Zhangjiagang Science and Technology Bureau","award":["ZKS2138"],"award-info":[{"award-number":["ZKS2138"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cerebral amyloid angiopathy (CAA) frequently co-occurs with Alzheimer's disease (AD), complicating the interpretation of biomarkers. Current diagnostic approaches rely largely on neuroimaging but remain constrained by limited accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic discrimination and pathological association of neuropathological scoring systems and fluid biomarkers for CAA using pathologically confirmed samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined 100 participants from the Alzheimer's Disease Neuroimaging Initiative with complete neuropathological assessments. Associations and diagnostic performance of amyloid-\u03b2 (A\u03b2)-related measures were evaluated using multivariable regression and receiver operating characteristic analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both Thal phase and the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) score were associated with CAA status. Cerebrospinal fluid (CSF) A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      , A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      , and A\u03b2\n                      <jats:sub>38<\/jats:sub>\n                      concentrations were significantly reduced in CAA, with CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      showing the greatest decrease and highest diagnostic accuracy [area under the curve (AUC) 0.962; sensitivity 88.6%; specificity 100%). Plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ratio was also markedly lower in CAA and demonstrated robust diagnostic discrimination (AUC 0.913; sensitivity 84.6%; specificity 100%). In contrast, inflammatory and neuronal injury markers did not differ significantly between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neuropathological scores and fluid biomarkers are associated with the presence and severity of CAA, but this association is confounded by co-existing advanced AD pathology. Despite high discriminative accuracy, the small control sample warrants cautious interpretation of specificity estimates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261433955","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:44:36Z","timestamp":1773467076000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic association of ante-mortem biomarkers with cerebral amyloid angiopathy in a cohort with high Alzheimer's disease comorbidity"],"prefix":"10.1177","volume":"10","author":[{"given":"Kemi","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengdan","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-9815","authenticated-orcid":false,"given":"Lingling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx047"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05277-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00114-X"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493020974464"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207510"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209386"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.783996"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70066"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016990"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12422"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14321"},{"key":"e_1_3_3_13_2","article-title":"Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia","volume":"12","author":"Shen XN","year":"2020","unstructured":"Shen XN, Li JQ, Wang HF, et al. Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia. Alzheimers Dement (Amst) 2020; 12: e12104.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.06.2266"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.6.869"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13030603"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv050"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.5414\/NP301564"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-019-0858-4"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002175"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01146-y"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230553"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2021.100010"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad159"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215208"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005030"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-023-01698-4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12506"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26610"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0281-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav2546"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873241260538"},{"key":"e_1_3_3_34_2","article-title":"Circulating proteomic biomarkers for cerebral amyloid angiopathy screening and risk stratification","volume":"21","author":"Xu J","year":"2025","unstructured":"Xu J, Su Y, Sha Y, et al. Circulating proteomic biomarkers for cerebral amyloid angiopathy screening and risk stratification. Alzheimers Dement 2025; 21: e70044.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.044784"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06361.x"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8362-2"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01457-0"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261433955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25424823261433955","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261433955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:44:38Z","timestamp":1773467078000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25424823261433955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":37,"alternative-id":["10.1177\/25424823261433955"],"URL":"https:\/\/doi.org\/10.1177\/25424823261433955","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"25424823261433955"}}