{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:31:14Z","timestamp":1781530274329,"version":"3.54.1"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antipsychotics are frequently prescribed off-label to manage behavioral and psychological symptoms of dementia but pose safety risks in older adults, including a 1.5\u20132.0-fold increased risk of mortality. The coronavirus disease (COVID-19) pandemic disrupted dementia care, increasing reliance on pharmacologic treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether the COVID-19 pandemic was associated with changes in the prevalence of antipsychotic prescribing among patients with dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Korean National Health Insurance Database, this study analyzed a random 50% sample of eligible individuals aged \u226560 years diagnosed with dementia between 2016 and 2021 (n\u2009=\u2009876,158; 9.8 million person-observations). Outcomes included the likelihood, duration, and number of antipsychotic prescriptions issued, characterizing pharmacologic management of dementia. Interrupted time series analysis assessed associations between the pandemic and relative changes in these outcomes, adjusting for demographic factors, comorbid burden, and seasonality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After the pandemic onset, there were relative slope increases per quarter of 1.5%, 3.2%, and 0.4% in the likelihood, duration, and number of prescriptions, respectively (all p\u2009&lt;\u20090.001; pre-pandemic levels: 0.172 patients prescribed, 12.97 days, and 18.10 prescriptions per person-quarter). Antipsychotic prescriptions decreased by 1.6% (p\u2009&lt;\u20090.001) during the first quarter after the outbreak but subsequently showed a progressive increase, reflecting prolonged care disruption after initial access barriers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The COVID-19 pandemic was associated with increased antipsychotic prescribing among patients with dementia. To mitigate similar effects in future public health crises, governments and healthcare providers should strengthen mental health support, non-pharmacological interventions, telehealth continuity, and tailored prescribing guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261435562","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:56:27Z","timestamp":1774425387000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between the coronavirus disease pandemic and antipsychotic drug prescriptions among patients with dementia"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8295-7767","authenticated-orcid":false,"given":"Kyungduk","family":"Hurh","sequence":"first","affiliation":[{"name":"Gachon University College of Medicine"},{"name":"Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Incheon, Republic of Korea"},{"name":"Yonsei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunkyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University"},{"name":"National Health Insurance Service Ilsan Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Yonsei University"},{"name":"Yonsei University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Statistics Korea. Senior statistics 2022 https:\/\/kostat.go.kr\/board.es?mid=a10301060500&bid=10820&act=view&list_no=420896&tag=&nPage=1&ref_bid= (accessed 5 October 2023)."},{"key":"e_1_3_2_3_2","volume-title":"Asia-Pacific report on population ageing 2022: trends, policies and good practices regarding older persons and population ageing","author":"United Nations Economic and Social Commission for Asia and the Pacific","year":"2022","unstructured":"United Nations Economic and Social Commission for Asia and the Pacific. Asia-Pacific report on population ageing 2022: trends, policies and good practices regarding older persons and population ageing. Bangkok: UN ESCAP, 2022."},{"key":"e_1_3_2_4_2","volume-title":"National dementia epidemiological surveillance in Korea 2023","author":"National Institute of Dementia","year":"2023","unstructured":"National Institute of Dementia. National dementia epidemiological surveillance in Korea 2023. Seoul: National Institute of Dementia, 2023. https:\/\/www.nid.or.kr\/info\/dataroom_view.aspx?bid=309 (accessed 30 January 2026). 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