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Regression analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among participants with low pIQ, elevated plasma p-tau 181 was more strongly associated with worse episodic memory. In stratified analyses, NfL, p-tau 181, and t-tau were differentially and inconsistently associated with cognitive outcomes, with varying strength based on pIQ grouping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A one-size-fits-all approach to biomarker-cognition associations interpretation may overlook important individual differences driven by pIQ. These exploratory analyses provide preliminary evidence to support future studies aimed at validating cognitive stratification in biomarker interpretation and interventions for individuals with low pIQ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261445643","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:38:47Z","timestamp":1777293527000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Low premorbid IQ effects biomarker\u2013cognition relationships: A pilot study"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-1075","authenticated-orcid":false,"given":"Lubnaa Badriyyah","family":"Abdullah","sequence":"first","affiliation":[{"name":"University of North Texas Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8039-418X","authenticated-orcid":false,"given":"Zhengyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Housini","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Hall","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sid","family":"O\u2019Bryant","sequence":"additional","affiliation":[{"name":"University of North Texas Health Science Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/12.8.711"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617702813248"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000569"},{"key":"e_1_3_3_5_2","volume-title":"Wechsler Test of Adult Reading: WTAR","author":"Wechsler D","year":"2001","unstructured":"Wechsler D. 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