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Noninvasive neuromodulation might restore brain plasticity and lead to clinically meaningful cognitive improvements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate feasibility and tolerability of a multi-field (four regions) extended (80-min-long) intervention using high-definition transcranial direct current stimulation (HD-tDCS) combined with computerized cognitive training (CCT) in participants with MCI and to explore its effects on cognition and brain functional connectivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Double-blinded, randomized proof-of-concept trial of daily sham HD-tDCS + CCT (n\u2009=\u20094) or anodal HD-tDCS + CCT (n\u2009=\u20094) for 15 sessions over 3 months. Four cortical regions were targeted using neuronavigation, including putative frontal coordinates of cognitive reserve and lateral parietal coordinates hypothesized to have robust hippocampal connectivity. Neurocognitive outcomes were assessed at 3 and 6 months and resting-state functional connectivity changes were evaluated at 3 months. Statistical analysis included independent sample t-tests, Wilcoxon rank-sum tests, and Bonferroni correction for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven subjects were eligible and interviewed, and 8 consented (73% consent rate). All 8 completed the trial with only minor adverse events (100% completion rate). Blinding was successful. A large but non-significant increase in Alzheimer's Disease Cooperative Study-Preclinical Alzheimer's Cognitive Composite scores at 6 months was observed in the anodal group (59.8%) compared with sham (24.5%). Significant declines were seen in left parietal cortex\u2013left caudal hippocampus connectivity (p\u2009=\u20090.004) and right intraparietal sulcus\u2013right frontal eye fields connectivity (p\u2009=\u20090.039) in the anodal group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The intervention was feasible and well tolerated. Findings suggest possible normalization of aberrant or compensatory hyperconnectivity in MCI. Larger studies are needed.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Clinical Trial Number:<\/jats:bold>\n                      NCT04246164\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261449802","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T15:09:51Z","timestamp":1779462591000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifield extended high-definition transcranial direct current stimulation in mild cognitive impairment: A proof-of-concept study on cognition and brain network connectivity"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-4196","authenticated-orcid":false,"given":"Elias","family":"Granadillo","sequence":"first","affiliation":[{"name":"Institute for Clinical and Translational Research - University of 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