{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:10:24Z","timestamp":1778771424837,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Jiangsu Province Key Medical Discipline","award":["ZDXK202216"],"award-info":[{"award-number":["ZDXK202216"]}]},{"name":"the Key Research and Development Program of Jiangsu Province of China","award":["BE2020620"],"award-info":[{"award-number":["BE2020620"]}]},{"name":"STI2030-Major Projects","award":["2022ZD0211800"],"award-info":[{"award-number":["2022ZD0211800"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81920108017"],"award-info":[{"award-number":["81920108017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82130036"],"award-info":[{"award-number":["82130036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["SJCX23_0670"],"award-info":[{"award-number":["SJCX23_0670"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although dynamic network reconfiguration is altered in Alzheimer's disease (AD), its pattern in subjective cognitive decline (SCD), an early preclinical stage, remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to identify the characteristics of dynamic network reconfiguration in SCD individuals compared to healthy controls (HCs) and AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Time-varying multilayer network models were built for AD (n\u2009=\u2009111), SCD (n\u2009=\u2009115), and HC (n\u2009=\u2009111) groups using the GenLouvain algorithm. We compared dynamic reconfiguration features across groups and examined how abnormal reconfiguration affects the relationship between amyloid-\u03b2 (A\u03b2) pathology and cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SCD individuals showed higher global recruitment and lower global integration than AD patients, and lower integration than HCs. At the nodal level, SCD was marked by increased recruitment and reduced integration in regions mainly within the default mode network (DMN) and somatomotor network (SMN). In SCD, recruitment in the left anterior insula and ventral frontal cortex linked A\u03b2 pathology to memory performance. In AD, integration in the left superior frontal gyrus mediated the effects of A\u03b2 on memory and verbal fluency. The combination of differences in nodal recruitment and integration across groups helped distinguish between healthy, SCD, and AD individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SCD individuals show distinct patterns of dynamic network reconfiguration, high recruitment, and low integration in DMN and SMN, offering new insights into early AD pathophysiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261451212","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:40:33Z","timestamp":1778769633000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The characteristic patterns of dynamic network reconfiguration underlying subjective cognitive decline"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-7153","authenticated-orcid":false,"given":"Zhihong","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-6122","authenticated-orcid":false,"given":"Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4190-8434","authenticated-orcid":false,"given":"Zhixin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7978-9042","authenticated-orcid":false,"given":"Wenqian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9957-2766","authenticated-orcid":false,"given":"Zheqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2537-3005","authenticated-orcid":false,"given":"Chengbing","family":"Gong","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8564-4023","authenticated-orcid":false,"given":"Yue","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China"},{"name":"Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University"},{"name":"Department of Neurology, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, \rChina"},{"name":"Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China"},{"name":"Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University"},{"name":"Department of Neurology, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, \rChina"},{"name":"Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-0319","authenticated-orcid":false,"given":"Yun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China"},{"name":"Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University"},{"name":"Department of Neurology, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, \rChina"},{"name":"Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30185-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.069"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705120114"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102533"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.11.025"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70158-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2021.12.031"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01878-z"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.158"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26291"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2020.0847"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13387"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad542"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.015"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119662"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.01.040"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13068"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.646017"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00764-6"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-55"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90034-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988711422528"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26215"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14843"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.074"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350312"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.11.052"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194144"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0619-2"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.05.078"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003171"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab133"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy042"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.26529"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.912895"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl244"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.064"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004533"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.05.028"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1080\/17588928.2019.1682985"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.02.002"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.10.030"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.3180"},{"key":"e_1_3_3_51_2","article-title":"Validation of plasma amyloid-\u03b2 42\/40 for detecting Alzheimer disease amyloid plaques","volume":"98","author":"Li Y","year":"2022","unstructured":"Li Y, Schindler SE, Bollinger JG, et al. Validation of plasma amyloid-\u03b2 42\/40 for detecting Alzheimer disease amyloid plaques. Neurology 2022; 98: e688\u2013e699.","journal-title":"Neurology"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261451212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25424823261451212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261451212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:40:35Z","timestamp":1778769635000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25424823261451212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":50,"alternative-id":["10.1177\/25424823261451212"],"URL":"https:\/\/doi.org\/10.1177\/25424823261451212","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"25424823261451212"}}