{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:51:32Z","timestamp":1782370292349,"version":"3.54.5"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    We report the case of a 46-year-old woman who presented with progressing, early-onset cognitive decline associated with atypical features due to a\n                    <jats:italic toggle=\"yes\">PSEN1<\/jats:italic>\n                    mutation. This case extends the known spectrum of clinical, radiological and pathological findings associated with this mutation.\n                  <\/jats:p>","DOI":"10.1177\/25424823261464623","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:42:30Z","timestamp":1782369750000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic challenges in early-onset Alzheimer's disease: Case report of a patient with\n                    <i>PSEN1<\/i>\n                    p.Asn135Ser mutation"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-6538","authenticated-orcid":false,"given":"Carolina","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Unidade Local de Sa\u00fade Lisboa Ocidental"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3517-8365","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Cabral","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade Lisboa Ocidental"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Almeida","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade Lisboa Ocidental"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-362X","authenticated-orcid":false,"given":"Filipe","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade Lisboa Ocidental"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9426-9390","authenticated-orcid":false,"given":"Diogo","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade Lisboa Ocidental"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-1883","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Alves","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade Lisboa Ocidental"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-020-01090-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810970"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30193-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2024.07.012"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000001089"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70127-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215167"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105082"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2015.08.004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13729"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlv028"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-005-0211-x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181732399"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00111-X"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261464623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25424823261464623","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261464623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T06:42:31Z","timestamp":1782369751000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25424823261464623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":14,"alternative-id":["10.1177\/25424823261464623"],"URL":"https:\/\/doi.org\/10.1177\/25424823261464623","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"article-number":"25424823261464623"}}