{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:49:40Z","timestamp":1782474580180,"version":"3.54.5"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"KLEF","award":["002"],"award-info":[{"award-number":["002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) is marked by the progressive loss of dopaminergic neurons in the substantia nigra and the accumulation of \u03b1-synuclein (\u03b1-syn) into amyloid fibrils and Lewy bodies. These aggregates impair synaptic function, disrupt proteostasis, compromise mitochondrial health, and drive neuroinflammation and oxidative stress. Clinical observations during the COVID-19 pandemic revealed accelerated motor deterioration and higher mortality among PD patients following SARS-CoV-2 infection, pointing to potential overlapping mechanisms with Alzheimer's disease, including protein misfolding, chronic inflammation, and oxidative damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate how the SARS-CoV-2 N-protein may accelerate \u03b1-syn aggregation using computational approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We employed a multimodal, label-free computational pipeline inspired by TopoBind to examine the topological maturation of patient-derived \u03b1-syn fibrils across preclinical (PDB 7V47, 8H03), mid-stage (7XO0, 7XO1), and late-stage (8H04, 7V48) PD phases. Per-residue features were extracted using 640-dimensional evolutionary scale modeling (ESM)-2 embeddings, solvent-accessible surface area, and persistent homology based on Vietoris\u2013Rips filtration of C\u03b1 coordinates (r\u2009=\u20090\u201320\u2005\u00c5, persistence threshold &gt; 0.8\u2005\u00c5). Predictions were validated using PyRosetta InterfaceAnalyzerMover, PRODIGY (\u0394G and Kd), and normal mode analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pipeline successfully identified key protein-protein interface residues on \u03b1-syn fibrils, achieving 74\u201392% overlap with PyRosetta results. Conserved interaction hotspots were located primarily in the non-amyloid component region, protofilament interfaces, and hydrophobic grooves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings demonstrate that fibril maturation involves progressive expansion of binding interfaces, offering a plausible topological mechanism by which SARS-CoV-2 N-protein can promote pathogenic \u03b1-syn conformers and contribute to long-term neurological complications following infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261464972","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:30:25Z","timestamp":1782473425000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Studies on topological maturation of \u03b1-synuclein fibrils in Parkinson's disease: Insights from persistent homology and SARS-CoV-2 acceleration of aggregation"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-0579","authenticated-orcid":false,"given":"Pranathi","family":"Jalapally","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, APJ Abdul Kalam Technological University, Thiruvananthapuram, India"},{"name":"Department of Computer Science and Engineering, Rajagiri School of Engineering &amp; Technology (Autonomous), Kochi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-2265","authenticated-orcid":false,"given":"Lakshmi Sowmya","family":"Emani","sequence":"additional","affiliation":[{"name":"Koneru Lakshmaiah Education Foundation Deemed to be University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sminu","family":"Izudheen","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Rajagiri School of Engineering &amp; Technology (Autonomous), Kochi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4801-3535","authenticated-orcid":false,"given":"KS","family":"Jagannatha Rao","sequence":"additional","affiliation":[{"name":"Koneru Lakshmaiah Education Foundation Deemed to be University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.736978"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci15121260"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092524"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-212779"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12070970"},{"key":"e_1_3_3_7_2","first-page":"104281","article-title":"New-onset parkinsonism as a COVID-19 infection sequela: a systematic review and meta-analysis","volume":"80","author":"Ali SS","year":"2022","unstructured":"Ali SS, Mumtaz A, Qamar MA, et al. 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