{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:06:23Z","timestamp":1784635583260,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mild cognitive impairment (MCI) is an important transitional stage between normal cognitive aging and dementia. Biomarker-based biological age may better capture physiological aging processes than chronological age, yet its association with the risk of developing MCI remains insufficiently studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to examine the association between Gompertz Law-Based Biological Age (Light BioAge) and incident MCI in a middle-aged and older Chinese population, and to explore whether social activeness modifies this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the China Health and Retirement Longitudinal Study, a nationally representative cohort. Light BioAge was calculated from chronological age, serum creatinine, fasting glucose, and C-reactive protein. Incident MCI was defined using age- and education-standardized cognitive assessments. Cox regressions were used to analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 9410 participants free of MCI at baseline, 1047 developed MCI during follow-up. Light BioAge was negatively associated with risk of MCI (hazards ratio (HR)\u2009=\u20090.99, 95% CI: 0.98\u20130.99). Compared to high Light BioAge, those in the moderate and low groups showed significantly lower risks of MCI (HR\u2009=\u20090.78, 95% CI: 0.65\u20130.94 and HR\u2009=\u20090.79, 95% CI: 0.65\u20130.97, respectively). The association were consistent across sex and different levels of social activeness, with no significant interaction observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower biological age, as estimated by Light BioAge, is independently associated with a reduced risk of MCI in middle-aged and older adults. The use of biomarker-based aging indicators may help identify individuals at higher risk of cognitive decline for early preventive strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261470071","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:45:33Z","timestamp":1784634333000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between Gompertz law-based biological age (GOLD BioAge) and incident mild cognitive impairment: Modifying role of social activeness"],"prefix":"10.1177","volume":"10","author":[{"given":"Yating","family":"Xiao","sequence":"first","affiliation":[{"name":"West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7908-4793","authenticated-orcid":false,"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1678212"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321913"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70221"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213616"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03640-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26900"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213794"},{"key":"e_1_3_3_10_2","article-title":"Gompertz Law-Based Biological Age (GOLD BioAge): a simple and practical measurement of biological ageing to capture morbidity and mortality risks","volume":"12","author":"Hao M","year":"2025","unstructured":"Hao M, Zhang H, Wu J, et al. Gompertz Law-Based Biological Age (GOLD BioAge): a simple and practical measurement of biological ageing to capture morbidity and mortality risks. Adv Sci (Weinh) 2025; 12: e01765.","journal-title":"Adv Sci (Weinh)"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcdhc.2026.1791782"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180439"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-22009-9_333"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-21107-2"},{"key":"e_1_3_3_15_2","volume-title":"Successful ageing in China: the importance of health behaviours","author":"Feng Z","year":"2021","unstructured":"Feng Z. Successful ageing in China: the importance of health behaviours. Erasmus University Rotterdam, 2021."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.41714"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610219000693"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.09.008"},{"key":"e_1_3_3_19_2","first-page":"516","article-title":"Progress in research of quantification of biological age","volume":"44","author":"Cao LM","year":"2023","unstructured":"Cao LM, Chen ST, Wang T. Progress in research of quantification of biological age. Zhonghua Liu Xing Bing Xue Za Zhi 2023; 44: 516\u2013520.","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbab192"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.12.009"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219686110"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2023.101061"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-019-05225-x"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007094"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0059-4"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1311765"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaf243"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012050536"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12910"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaf150"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261470071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25424823261470071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261470071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:45:34Z","timestamp":1784634334000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25424823261470071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":30,"alternative-id":["10.1177\/25424823261470071"],"URL":"https:\/\/doi.org\/10.1177\/25424823261470071","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"25424823261470071"}}