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Circulating lipid parameters have been increasingly investigated as accessible biomarkers for dementia risk and cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review and synthesize existing evidence on the relationship between circulating lipid parameters and dementia risk, Alzheimer's disease, and cognitive decline, with particular consideration of their potential utility in resource-limited settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature review was conducted in accordance with PRISMA guidelines. Studies published between 2000 and May 2025 evaluating associations between lipid profiles and cognitive outcomes, dementia, or neurodegenerative disease were included and narratively synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Evidence across studies suggests that lipid dysregulation is associated with dementia-related outcomes, although findings remain heterogeneous. Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides were frequently associated with increased risk of dementia, Alzheimer's disease, or cognitive decline, whereas high-density lipoprotein cholesterol generally showed protective associations. Several studies also identified prognostic value in composite lipid ratios and lipid variability measures. However, the strength and direction of associations varied according to age, sex, timing of lipid assessment, and study population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Circulating lipid parameters alone are insufficient as definitive diagnostic biomarkers. However, when interpreted in a population-specific and life-course context, they may contribute to early risk stratification and complement neuropsychological screening, particularly in resource-limited settings where access to advanced neuroimaging and cerebrospinal fluid testing is restricted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261475263","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:41:34Z","timestamp":1785764494000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood lipids as accessible biomarkers for early dementia risk screening: Bridging diagnostic gaps in resource-limited settings"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6365-5213","authenticated-orcid":false,"given":"Foster","family":"Appiah","sequence":"first","affiliation":[{"name":"University of Cape Coast"},{"name":"Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Nalerigu Nursing and midwifery college, Nalerigu, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Larbi","family":"Simpong","sequence":"additional","affiliation":[{"name":"University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Nkrumah","family":"Osei","sequence":"additional","affiliation":[{"name":"University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dogah","sequence":"additional","affiliation":[{"name":"University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Marfo","sequence":"additional","affiliation":[{"name":"University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell Hubert","family":"Antwi","sequence":"additional","affiliation":[{"name":"University of Cape Coast"},{"name":"Department of Medical Laboratory Science, Faculty of Health Sciences, Koforidua Technical University, Koforidua, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Mawutor","family":"Donkor","sequence":"additional","affiliation":[{"name":"University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwaku Sarfo","family":"Manu","sequence":"additional","affiliation":[{"name":"Alzheimer's and Related Association of Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1173-1493","authenticated-orcid":false,"given":"Ansumana","family":"Bockarie","sequence":"additional","affiliation":[{"name":"University of Cape Coast"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019. 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