{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:27:39Z","timestamp":1786724859036,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amyloid-\u03b2 (A\u03b2) accumulation begins before cognitive impairment, highlighting the need for scalable blood-based biomarkers to identify individuals at risk during the preclinical stage of Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether plasma %p-tau217 detects A\u03b2-PET positivity and whether longitudinal plasma %p-tau217 change is associated with early A\u03b2 accumulation in cognitively unimpaired participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective longitudinal study included 98 cognitively unimpaired ADNI participants with plasma %p-tau217, plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      , A\u03b2-PET, and clinical\/genetic data. A\u03b2-PET positivity was defined as Centiloid (CL)\u2009\u2265\u200940. Among participants with baseline A\u03b2-PET &lt;40 CL, participant-specific annual slopes for A\u03b2-PET CL and plasma biomarkers were estimated from matched longitudinal measurements using linear mixed-effects models. Regression and receiver operating characteristic analyses assessed associations with A\u03b2-PET change and discrimination of A\u03b2-PET positivity and A\u03b2 accumulator status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma %p-tau217 showed excellent discrimination of A\u03b2-PET positivity (area under the curve (AUC)\u2009=\u20090.962) and yielded a higher AUC than plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      . In participants with baseline A\u03b2-PET &lt;40 CL, longitudinal plasma %p-tau217 slope was the only plasma biomarker independently associated with annual A\u03b2-PET CL increase in fully adjusted models (\u03b2\u2009=\u20091.38; FDR-adjusted p\u2009&lt;\u20090.001). Plasma %p-tau217 slope also yielded a higher AUC for A\u03b2 accumulator status than baseline plasma %p-tau217.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma %p-tau217 is a strong blood-based biomarker for detecting A\u03b2-PET positivity in cognitively unimpaired individuals. Longitudinal plasma %p-tau217 change provides additional information beyond baseline plasma biomarkers and may support enrichment or monitoring strategies in Alzheimer's disease prevention trials, pending validation in larger independent cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25424823261478592","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:29:23Z","timestamp":1786721363000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma p-tau217 for detecting A\u03b2-PET positivity and tracking early amyloid accumulation in cognitively unimpaired ADNI participants"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9079-4542","authenticated-orcid":false,"given":"Emadoddin","family":"Kazemi","sequence":"first","affiliation":[{"name":"Arak University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Alzheimer's Disease Neuroimaging Initiative *","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00403-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.13855"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13542"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2619"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13764"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00587-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0478-z"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12748"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13761"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-026-02080-x"},{"key":"e_1_3_3_16_2","first-page":"1797","article-title":"Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer\u2019s disease","volume":"28","author":"Mil\u00e0-Alom\u00e0 M","year":"2022","unstructured":"Mil\u00e0-Alom\u00e0 M, Ashton NJ, Shekari M, et al. Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer\u2019s disease. Nat Med 2022; 28: 1797\u20131801.","journal-title":"Nat Med"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011524"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa286"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02074-w"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01642-1"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-71269-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114022"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-71732-1"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70662"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.3217"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261478592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25424823261478592","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261478592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:29:24Z","timestamp":1786721364000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25424823261478592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":24,"alternative-id":["10.1177\/25424823261478592"],"URL":"https:\/\/doi.org\/10.1177\/25424823261478592","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"25424823261478592"}}