{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:18:54Z","timestamp":1788967134850,"version":"build-2803163510"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Lecanemab is an anti\u2013amyloid-\u03b2 monoclonal antibody used for the treatment of early Alzheimer's disease. Herein, we report a 46-year-old woman who developed headache, fever, disorientation, and impaired consciousness 10 months after starting lecanemab. Magnetic resonance imaging revealed a small focal subcortical fluid-attenuated inversion recovery hyperintense lesion and bilateral occipital leptomeningeal enhancement without detectable hemorrhagic findings on T2*-weighted gradient-recalled echo imaging. Cerebrospinal fluid revealed mononuclear pleocytosis and markedly elevated interleukin-6. Infectious studies and neuronal surface antibodies were negative. High-dose corticosteroid therapy led to rapid clinical improvement. These findings support a diagnosis of steroid-responsive inflammatory leptomeningeal encephalitis temporally associated with lecanemab.<\/jats:p>","DOI":"10.1177\/25424823261483284","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:38:56Z","timestamp":1788964736000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Steroid-responsive inflammatory leptomeningeal encephalitis temporally associated with lecanemab therapy: A case report"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8349-8595","authenticated-orcid":false,"given":"Yuichiro","family":"Tagane","sequence":"first","affiliation":[{"name":"Hiroshima University Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-5538","authenticated-orcid":false,"given":"Masahiro","family":"Nakamori","sequence":"additional","affiliation":[{"name":"Hiroshima University Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Ishida","sequence":"additional","affiliation":[{"name":"Hiroshima University Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saya","family":"Tsuchigauchi","sequence":"additional","affiliation":[{"name":"Hiroshima University Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-0772","authenticated-orcid":false,"given":"Takamichi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Hiroshima University Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0806-4960","authenticated-orcid":false,"given":"Yu","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Hiroshima University Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-8717","authenticated-orcid":false,"given":"Hirofumi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Hiroshima University Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01441-8"},{"key":"e_1_3_3_4_2","article-title":"Fatal iatrogenic cerebral amyloid-related encephalitis in a woman treated with lecanemab for Alzheimer\u2019s disease","volume":"20","author":"Solopova E","year":"2025","unstructured":"Solopova E. Fatal iatrogenic cerebral amyloid-related encephalitis in a woman treated with lecanemab for Alzheimer\u2019s disease. Alzheimers Dement 2025; 20: e090928.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705971"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-025-04302-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit458"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00401-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13826"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43933-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00268.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003613"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200559"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251404505"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261483284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25424823261483284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25424823261483284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:38:57Z","timestamp":1788964737000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25424823261483284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":13,"alternative-id":["10.1177\/25424823261483284"],"URL":"https:\/\/doi.org\/10.1177\/25424823261483284","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"25424823261483284"}}