{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:23:20Z","timestamp":1786116200147,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The CRISPR Journal"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>On May 12, 2025, the US Court of Appeals for the Federal Circuit issued its second decision in the long-running CRISPR patent dispute between the Regents of the University of California and related institutions (CVC) and the Broad Institute. This Perspective recounts the principal dispute to date, reviews the Federal Circuit\u2019s recent opinion, and provides a critique of its analysis. In particular, this Perspective highlights how the decision is self-contradictory and in tension with patent law\u2019s conception doctrine\u2014when an inventor has formed a \u201cdefinite and permanent\u201d idea of an invention in the mind or whether the invention was little more than a \u201cbare hope\u201d of a result. This Perspective briefly concludes with the implications of this recent decision and where the underlying dispute is likely headed.<\/jats:p>","DOI":"10.1177\/25731599251361362","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:24:14Z","timestamp":1759249454000},"page":"317-320","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A \u201cBare Hope of A Result\u201d: The Second CRISPR Patent Appeal"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-9261","authenticated-orcid":false,"given":"Jacob S.","family":"Sherkow","sequence":"first","affiliation":[{"name":"College of Law, Carle Illinois College of Medicine, European Union Center, Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Champaign, Illinois, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"Regents of the Univ. of Cal. v. Broad Institute Inc. No. 2022-1594. Fed. Cir 2025."},{"key":"e_1_3_1_3_2","unstructured":"Regents of the Univ. of Cal. v. Broad Institute Inc. Patent Interference No. 106 115 Decision on Priority (P.T.A.B. Feb. 29 2022)."},{"key":"e_1_3_1_4_2","unstructured":"U.S. Patent No. 10 266 850."},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/crispr.2022.0033"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/crispr.2018.0044"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/crispr.2017.0013"},{"key":"e_1_3_1_8_2","unstructured":"Broad Institute Inc. v. Regents of the Univ. of Cal. Patent Interference No. 106 048 Declaration (P.T.A.B. Jan. 11 2016)."},{"key":"e_1_3_1_9_2","unstructured":"Broad Institute Inc. v. Regents of the Univ. of Cal. Patent Interference No. 106 048 Decision on Motions (P.T.A.B. Feb. 15 2017)."},{"key":"e_1_3_1_10_2","unstructured":"Regents of the Univ. of Cal. v. Broad Institute Inc. 903 F.3d 1286. Fed. Cir 2018."},{"key":"e_1_3_1_11_2","unstructured":"BJ Services Co. v. Halliburton Energy Services 338 F.3d 1368. Fed. Cir 2003."},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","unstructured":"Heard v. Burton 333 F.2d 239 (C.C.P.A. 1964).","DOI":"10.1080\/00034983.1964.11686251"},{"key":"e_1_3_1_13_2","article-title":"Rutter, 243 F. 3d 1345","author":"Hitzeman V","year":"2001","unstructured":"Hitzeman V. Rutter, 243 F. 3d 1345. Fed. Cir, 2001.","journal-title":"Fed. Cir"},{"key":"e_1_3_1_14_2","unstructured":"US Patent & Trademark Office Inventorship Guidance for AI-Assisted Inventions 89 Fed. Reg. 10043 (Feb. 13 2024)."},{"key":"e_1_3_1_15_2","unstructured":"Boehm E Flatt E Palazzoli F. CRISPR technology: Patent & license landscapes. Swiss Center for Business and Technology Intelligence. 2024. Available from: https:\/\/www.ige.ch\/fileadmin\/user_upload\/recht\/national\/e\/20231388_IPI_CRISPR_Patent_License_Landscape_revised_Final_16_02_24.pdf"},{"key":"e_1_3_1_16_2","unstructured":"Mast J. After decade-long dispute over CRISPR-Cas9 Editas strikes deal with Vertex to cash in. STAT. 2023. 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