{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:31:06Z","timestamp":1793968266057,"version":"4.8.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The endocannabinoid system regulates numerous physiological functions, including the stress response, and is frequently implicated in stress-related disorders. Understanding how this system is altered during stress is therefore critical for both diagnostic and therapeutic applications. The primary ligands of the endocannabinoid system, N-arachidonoylethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG), are measurable in circulation and are commonly used to assess endocannabinoid function under various conditions in humans. More recently, endocannabinoids have also been detected in saliva; however, the physiological relevance of their salivary responses remains poorly understood. The present study, therefore, aims to compare stress-induced changes in endocannabinoid and related molecule levels in saliva and plasma, with the goal of advancing understanding of stress-related alterations in salivary endocannabinoids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The Maastricht Acute Stress Test was used to induce acute stress in 59 participants, with plasma and saliva samples collected at baseline, immediately after stress, and 25-min post-stress. Stress-induced changes in AEA, 2-AG, N-palmitoylethanolamine, N-oleoylethanolamine, arachidonic acid, cortisol, cortisone, and dehydroepiandrosterone sulfate (DHEA-S) were measured using liquid chromatography\u2014tandem mass spectrometry. Norepinephrine was also analyzed in plasma using an enzyme-linked immunosorbent assay. Changes over time and associations among these analytes in response to stress were then examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Salivary endocannabinoid concentrations were independently stress-responsive of those in plasma, suggesting they reflect distinct physiological functions. Although changes in salivary endocannabinoid concentrations were not associated with changes in plasma norepinephrine, post-stress changes in salivary 2-AG correlated with changes in DHEA-S and subjective stress ratings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The findings from this study provide new evidence that salivary endocannabinoids offer a novel approach to examining the endocannabinoid system during the stress response and may reflect its crosstalk with other physiological systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785125251387514","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T10:24:28Z","timestamp":1760351068000},"page":"249-260","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Stress Responsivity of Endocannabinoids and Related Biomolecules in Plasma and Saliva"],"prefix":"10.1177","volume":"11","author":[{"given":"Jessica","family":"Hargreaves","sequence":"first","affiliation":[{"name":"School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Jarvis","sequence":"additional","affiliation":[{"name":"School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalisa","family":"Amir Hamzah","sequence":"additional","affiliation":[{"name":"School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Turner","sequence":"additional","affiliation":[{"name":"Yates Lab, Scripps Research Institute, La Jolla, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J.","family":"Ney","sequence":"additional","affiliation":[{"name":"School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1470919"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2437"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)44667-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0387"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(03)00079-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2007.11.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.07.002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.166"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.12.030"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-88955-7_14"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4036"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125527"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-018-0051-5"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-90877-1.00013-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00315"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.130"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21897"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/can.2023.0246"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2020.122252"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2023.106296"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2021.108022"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042399"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17987-2"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020623100816"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2024.107007"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.04.012"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000118611"},{"key":"e_1_3_3_29_2","volume-title":"Physiology, Stress Reaction. 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