{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:50:57Z","timestamp":1777481457367,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      The endocannabinoid system (ECS) is increasingly recognized as an important regulator of many physiological systems. People who use products derived from\n                      <jats:italic toggle=\"yes\">Cannabis sativa<\/jats:italic>\n                      L. are exposed to exogenous cannabinoids. The influence of this exogenous exposure on the ECS is unclear. People who use cannabis have demonstrated lower basal levels of endocannabinoids, but the dynamic response of their ECS to a controlled stimulus is unknown. Our study purpose was to compare circulating concentrations of the endocannabinoid\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      -arachidonoylethanolamine (anandamide, AEA) and subjective experiences between people who use cannabis and those who do not, during and following a standardized exercise stimulus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty adults (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8 who regularly use cannabis [age: 21\u201332 years; 5\/3 males\/females] and\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12 who do not use cannabis [age: 21\u201339 years; 7\/5 males\/females]) completed a 1-h treadmill run at an intensity equivalent to 65% of peak oxygen uptake. Arterialized-venous blood was collected prior to, during (including the last minute of exercise), and 15 min following exercise for determination of anandamide concentration. The subjective experiences of the participants during and after the run were assessed with responses to several questions assessed on a Likert scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with controls, the cannabis use group had lower AEA concentrations at end-exercise (0.47 \u00b1 0.13 vs. 0.33 \u00b1 0.10 ng\/mL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.015) and 15-min post-exercise (0.57 \u00b1 0.17 vs. 0.38 \u00b1 0.18 ng\/mL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001). The cannabis use group also had worse mood (3.25 \u00b1 1.03\n                      <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                      2.29 \u00b1 1.34; main effect of condition\n                      <jats:italic toggle=\"yes\">p =<\/jats:italic>\n                      0.05) and higher probability of feeling pain (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Habitual cannabis use was associated with diminished AEA response, worse mood, and more pain during\/following exercise. These pilot data might have implications for clinical outcomes associated with cannabis use, including cannabis use disorder and withdrawal, as well as potentially for exercise adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785125261428008","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:24:33Z","timestamp":1772259873000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Regular Cannabis Use is Associated with a Diminished Anandamide Response to a Standard Exercise Stimulus: A Pilot Study"],"prefix":"10.1177","author":[{"given":"Taylor R.","family":"Ewell","sequence":"first","affiliation":[{"name":"Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Bomar","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate E.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa T.","family":"Stallsmith","sequence":"additional","affiliation":[{"name":"Department of Psychology, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory P.","family":"Dooley","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7706-0912","authenticated-orcid":false,"given":"Christopher","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hollis C.","family":"Karoly","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2008.00104.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.5041\/rmmj.10129"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/10738584211069981"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.112706"},{"issue":"4","key":"e_1_3_3_6_2","first-page":"477","article-title":"Historical trends in cannabis use among U.S. adults ages 19\u201355, 2013\u20132021","volume":"85","author":"Patrick ME","year":"2024","unstructured":"Patrick ME, , Pang YC, , Terry-Mcelrath YM, et al. 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