{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:58:34Z","timestamp":1793131114923,"version":"4.5.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"CIMA Group","award":["N.A"],"award-info":[{"award-number":["N.A"]}]},{"name":"SRE Wellness","award":["N.A"],"award-info":[{"award-number":["N.A"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cannabis &amp; Cannabinoid Research"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Edibles have become the second-most used cannabis product in legal U.S. states, wherein 64% of cannabis consumers reported using edibles within the past year. Among expansions to the legal cannabis industry are the newly marketed \u201cfast-acting\u201d edible compounds, which may address many of the issues associated with edible use related to overdose and dose management. The study hypotheses were that fast-acting edibles would reach peak concentration significantly faster than standard edibles and placebo edibles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty participants completed three arms within-subjects designed study to test hypotheses. The three arms were ingestion of a (1) fast-acting edible, (2) a standard edible, and (3) a \u03949-tetrahydrocannabinol (THC) terpene-derived placebo edible that was indistinguishable from the two THC-containing edibles. Blood plasma was analyzed for the presence of THC and THC analytes. The pharmacokinetic parameters tested were time to max concentration (Tmax), maximum concentration (Cmax), terminal half-life (t\n                      <jats:sub>1\/2<\/jats:sub>\n                      ), and area under the curve (AUC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Results supported study hypotheses in that Tmax was significantly faster for the fast-acting edible, observed 30 min post-ingestion and, on average, 30 min earlier than the Tmax for the standard edible. There were no significant differences between the fast-acting and standard edibles on Cmax, t\n                      <jats:sub>1\/2<\/jats:sub>\n                      , and AUC; however, both the fast-acting and standard edibles were significantly different compared with the placebo across all pharmacokinetic parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The results indicate that the microencapsulation technology used to create the fast-acting edible enabled analyte concentrations to peak significantly faster compared to the standard and placebo edibles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785125261441366","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:47:20Z","timestamp":1775803640000},"page":"385-395","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacokinetic Differences Between Fast-Acting, Standard, and Placebo Cannabis Edibles"],"prefix":"10.1177","volume":"11","author":[{"given":"Bradley T.","family":"Conner","sequence":"first","affiliation":[{"name":"Department of Psychology, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychology, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel M.","family":"DiCecco","sequence":"additional","affiliation":[{"name":"Department of Psychology, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira L.","family":"Sturgess","sequence":"additional","affiliation":[{"name":"Department of Psychology, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hollis C.","family":"Karoly","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Dooley","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Azuca, Inc., Denver, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hennesy","sequence":"additional","affiliation":[{"name":"Wana Brands, LLC, Boulder, Colorado, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Cannabis Policy Impacts Public Health and Health Equity","author":"Boyle EB","year":"2024","unstructured":"Boyle EB, , Hurd YL, , Teutsch SM, , National Academies of Sciences. & Engineering, and Medicine. 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