{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:58:44Z","timestamp":1777881524544,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Cisplatin (Cis), a key cancer chemotherapy drug, faces limitations such as dose-dependent side effects and resistance. Photobiomodulation therapy (PBMT) shows promise as an adjuvant therapy to enhance Cis efficacy and reduce side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A systematic review was conducted to evaluate the combined effects of PBMT and Cis on various cancers. After searching five databases using relevant keywords, nine studies were included, encompassing both in vitro and in vivo models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Most in vitro studies showed a synergistic effect, with enhanced cancer cell inhibition, apoptosis induction, and reduced cell viability compared with Cis alone. The animal model confirmed these findings, showing PBMT mitigated Cis-induced acute renal failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mechanistically, PBMT may increase reactive oxygen species generation, cytochrome c release, modulate cellular metabolism, and involve the miR-124\/STAT3 signaling pathway. Combining PBMT with Cis appears to be a safe and effective cancer treatment strategy, synergistically inhibiting cancer cell growth and reducing side effects. Further clinical trials are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785478251372762","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:59:32Z","timestamp":1770631172000},"page":"468-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Enhancement of Cisplatin Anticancer Efficacy by Photobiomodulation Therapy: A Systematic Review"],"prefix":"10.1177","volume":"43","author":[{"given":"Emad","family":"Jafarzadeh","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereshtehsadat","family":"Jalali","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences (SBMUS), Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaber","family":"Zafari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran."},{"name":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Fakhari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"issue":"4","key":"e_1_3_6_2_2","article-title":"Overcoming Cisplatin\u2019s Challenges: A promising future in cancer care; a comprehensive review","volume":"13","author":"Nazari NA","year":"2023","unstructured":"Nazari NA, , Sarajar BO, , Azarshin SZ, et al. Overcoming Cisplatin\u2019s Challenges: A promising future in cancer care; a comprehensive review. Int J Med Toxicol Forensic Med, 2023; 13(4).","journal-title":"Int J Med Toxicol Forensic Med"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2024.101946"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70508"},{"issue":"2","key":"e_1_3_6_5_2","first-page":"41","article-title":"Systematic review of fecal and mucosa-associated microbiota compositional shifts in colorectal cancer","volume":"8","author":"Karimi Z","year":"2020","unstructured":"Karimi Z, , Ghazbani A, , Kashefian Naeeini S, et al. Systematic review of fecal and mucosa-associated microbiota compositional shifts in colorectal cancer. Iran J Colorectal Res, 2020; 8(2):41\u201364.","journal-title":"Iran J Colorectal Res"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2023.17"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01255"},{"issue":"06","key":"e_1_3_6_8_2","first-page":"2757","article-title":"Low Level Laser Therapy (LLLT) mechanism of action, application and laser light therapy devices in physical therapy","volume":"7","author":"Ali AO","year":"2024","unstructured":"Ali AO, , Najm FMS, , Muhammad Z-A, et al. Low Level Laser Therapy (LLLT) mechanism of action, application and laser light therapy devices in physical therapy. J Curr Med Res Opin, 2024; 7(06):2757\u20132765.","journal-title":"J Curr Med Res Opin"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.3889\/oamjms.2020.4561"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.04.014"},{"issue":"3","key":"e_1_3_6_12_2","first-page":"1291","article-title":"Modulation of tumor cell metabolism by laser photochemotherapy with cisplatin or zoledronic acid in vitro","volume":"38","author":"Heymann PGB","year":"2018","unstructured":"Heymann PGB, , Henkenius KSE, , Ziebart T, et al. Modulation of tumor cell metabolism by laser photochemotherapy with cisplatin or zoledronic acid in vitro. Anticancer Res, 2018; 38(3):1291\u20131301.","journal-title":"Anticancer Res"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.13152"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03386-y"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12442"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2021.17"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-023-03718-0"},{"issue":"1","key":"e_1_3_6_18_2","first-page":"1134","article-title":"Evaluating the regenerative potential of low level laser and\/or epidermal growth factor therapies in cisplatin induced acute renal failure in rats","volume":"46","author":"Kassab KN","year":"2013","unstructured":"Kassab KN, , Hassan AI, , Khater MS, et al. Evaluating the regenerative potential of low level laser and\/or epidermal growth factor therapies in cisplatin induced acute renal failure in rats. Int J Med Med Sci, 2013; 46(1):1134.","journal-title":"Int J Med Med Sci"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1608"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-56605-1"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2019.103959"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-16-4"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1109\/JSTQE.2016.2561201"},{"issue":"2","key":"e_1_3_6_24_2","first-page":"58","article-title":"Biological effects of low level laser therapy","volume":"5","author":"Farivar S","year":"2014","unstructured":"Farivar S, , Malekshahabi T, , Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci, 2014; 5(2):58\u201362.","journal-title":"J Lasers Med Sci"},{"issue":"53","key":"e_1_3_6_25_2","article-title":"Oral mucositis due to high-dose chemotherapy and\/or head and neck radiation therapy","volume":"2019","author":"Lalla RV","year":"2019","unstructured":"Lalla RV, , Brennan MT, , Gordon SM, et al. Oral mucositis due to high-dose chemotherapy and\/or head and neck radiation therapy. JNCI Monogr, 2019; 2019(53):lgz011.","journal-title":"JNCI Monogr"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-011-1202-0"},{"key":"e_1_3_6_27_2","article-title":"LOW-Intensity ultrasound enhanced the antitumor effects of cisplatin in non-small cell lung cancer cells via inhibiting MIR-124\/STAT3 Signaling","volume":"17","author":"Peng L","year":"2018","unstructured":"Peng L, , Luo Z, , Liu D, et al. LOW-Intensity ultrasound enhanced the antitumor effects of cisplatin in non-small cell lung cancer cells via inhibiting MIR-124\/STAT3 Signaling. Excli J, 2018; 17.","journal-title":"Excli J"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135083"}],"container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25785478251372762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25785478251372762","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25785478251372762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:45:20Z","timestamp":1777596320000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25785478251372762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/25785478251372762"],"URL":"https:\/\/doi.org\/10.1177\/25785478251372762","relation":{},"ISSN":["2578-5478","2578-5478"],"issn-type":[{"value":"2578-5478","type":"print"},{"value":"2578-5478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}