{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:16:43Z","timestamp":1783603003738,"version":"3.55.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The current study sought to explore the impact of a novel noninvasive treatment called transcranial photobiomodulation (PBM) on resting-state functional connectivity (rsFC) of the cerebellum in individuals with a history of repetitive head acceleration events (RHAEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>RHAEs are associated with cumulative neurological compromise, including chronic alterations in rsFC; however, few treatments have been investigated to mitigate these effects. A recent study by our team demonstrated that PBM treatment led to improvements in measures of balance and motor function in adults with RHAE exposure. Due to the cerebellum\u2019s role in motor functioning and its connectivity with cerebral regions targeted by PBM, we sought to examine changes in the rsFC of the cerebellum following PBM treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty individuals with RHAE used an at-home PBM headset with an intranasal cannula for 20 min every other day for a period of 8\u201310 weeks. A total of 240 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      of red and near-infrared light was administered to cortical nodes of the default mode network (DMN) and subcortical structures in each session. Using resting-state functional magnetic resonance imaging, rsFC was measured before and after treatment in 11 cerebellar seed regions associated with the DMN, salience network (SN), and frontoparietal network (FPN).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We observed an overall decrease in between-network connectivity and an increase in within-network connectivity after PBM treatment, particularly in the SN and FPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results suggest that PBM may improve network efficiency of the cerebellum by regulating overactive connections and increasing network segregation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785478251376477","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:14:32Z","timestamp":1773234872000},"page":"475-489","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Improvements in Resting-State Functional Connectivity of the Cerebellum after Transcranial Photobiomodulation in Adults with a History of Repetitive Head Acceleration Events"],"prefix":"10.1177","volume":"43","author":[{"given":"Finian","family":"Keleher","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Esopenko","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M.","family":"Lindsey","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary R.","family":"Newsome","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."},{"name":"H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula K.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."},{"name":"Office of Research, Rocky Mountain University of Health Professions, Provo, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Hovenden","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayna","family":"Thayn","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."},{"name":"Neuroscience Center, Brigham Young University, Provo, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary A.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Mullen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"Department of Physical Medicine &amp; Rehabilitation, University of Utah School of Medicine, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Velez","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma N.","family":"Read","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. Wahlen Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Larson","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Brigham Young University, Provo, Utah, USA."},{"name":"Department of Psychology, Brigham Young University, Provo, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance E.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"Department of Exercise Science, Brigham Young University, Provo, Utah, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer W.","family":"Liebel","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA."},{"name":"George E. 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