{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:58:43Z","timestamp":1777881523469,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["316287\/2023-7"],"award-info":[{"award-number":["316287\/2023-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    This split-mouth randomized study evaluated the effect of in-office tooth whitening with violet Light-Emitting Diode (LED) on gingival inflammation, assessed by gingival crevicular fluid (GCF) interleukin-6 (IL-6) level, histomorphology, and immunohistochemical analysis of Tumor Necrosis Factor (TNF-\u03b1) and Cluster of Differentiation 8 (CD8) expression, with and without gingival barrier protection. Thirteen volunteers requiring gingivoplasty were included. The whitening procedure was performed with parameters of 400 nm, 134J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , and 20 cycles of 30 sec with 60 sec of standby. Gingival surgery was performed 48 h post-whitening for histomorphology analysis, while GCF IL-6 levels were quantified using an Enzyme-Linked Immunosorbent Assay (ELISA). We also attempted immunohistochemical analysis of TNF-\u03b1 and CD8 expression; however, the small gingival specimens, which were primarily epithelial tissue, limited the reliability of the results. No statistically significant differences were observed between sides for histomorphology or GCF IL-6. These findings suggest that LED whitening without a gingival barrier may not induce gingival inflammation. However, further studies with larger and gender-balanced samples, extended time points, and additional cytokine markers are needed to confirm these results.\n                  <\/jats:p>","DOI":"10.1177\/25785478251380384","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T16:34:01Z","timestamp":1768840441000},"page":"559-563","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Gingival Inflammation after Tooth Whitening In-Office with Violet LED: A Randomized Controlled Clinical Trial with a Split-Mouth Design"],"prefix":"10.1177","volume":"43","author":[{"given":"Ana Eliza Castanho Garrini","family":"dos Santos","sequence":"first","affiliation":[{"name":"Biophotonics-Medicine Postgraduate Program, UNIVERSIDADE NOVE DE JULHO (UNINOVE), Universidade Nove de Julho (UNINOVE), S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima Antonia Aparecida","family":"Zanin","sequence":"additional","affiliation":[{"name":"Biophotonic Center of Institute Brugnera and Zanin, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dacio Ant\u00f4nio Pantano","family":"Junior","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Faculdade de Odontologia, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiris","family":"Silva","sequence":"additional","affiliation":[{"name":"Biophotonics-Medicine Postgraduate Program, UNIVERSIDADE NOVE DE JULHO (UNINOVE), Universidade Nove de Julho (UNINOVE), S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Muller","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein, Hospital Israelita Albert Einstein, S\u00e3o Paulo, Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda Set\u00fabal Dextro","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Biophotonics-Medicine Postgraduate Program, UNIVERSIDADE NOVE DE JULHO (UNINOVE), Universidade Nove de Julho (UNINOVE), S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara Jansiski","family":"Motta","sequence":"additional","affiliation":[{"name":"Biophotonics-Medicine Postgraduate Program, UNIVERSIDADE NOVE DE JULHO (UNINOVE), Universidade Nove de Julho (UNINOVE), S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Kalil","family":"Bussadori","sequence":"additional","affiliation":[{"name":"Biophotonics-Medicine Postgraduate Program, UNIVERSIDADE NOVE DE JULHO (UNINOVE), Universidade Nove de Julho (UNINOVE), S\u00e3o Paulo, Brazil."},{"name":"Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho, UNINOVE, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Brugnera Junior","sequence":"additional","affiliation":[{"name":"Biophotonic Center of Institute Brugnera and Zanin, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Carolina Ratto Tempestini","family":"Horliana","sequence":"additional","affiliation":[{"name":"Biophotonics-Medicine Postgraduate Program, UNIVERSIDADE NOVE DE JULHO (UNINOVE), Universidade Nove de Julho (UNINOVE), S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2016.4111"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02835-x"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2010.0081"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.4047"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-021414"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2018.4567"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.4172\/2161-1122.1000459"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2018.06.021"},{"key":"e_1_3_7_10_2","first-page":"95","article-title":"Clareamento Dental: Nova perspectiva para a Odontologia est\u00e9tica","volume":"71","author":"Panh\u00f3ca VH","year":"2017","unstructured":"Panh\u00f3ca VH, , de AN, , Rastelli S, , Zanin FA, , Bagnato VS, , Brugnera A.Jr, Clareamento Dental: Nova perspectiva para a Odontologia est\u00e9tica. 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