{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:12:34Z","timestamp":1778069554548,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2023\/08195-7"],"award-info":[{"award-number":["2023\/08195-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To investigate the effectiveness of the acai photosensitizer (\n                      <jats:italic toggle=\"yes\">Euterpe oleracea<\/jats:italic>\n                      Martius), combined or not with low-intensity laser, in reducing\n                      <jats:italic toggle=\"yes\">Streptococcus mutans<\/jats:italic>\n                      in carious dentin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Due to its high penetration power and coloring ability, acai presents a promising and unexplored option for use as a photosensitizer in antimicrobial photodynamic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We selected 60 permanent third molars and exposed their coronal dentin. After producing dentin carious lesions, we randomly divided the teeth into four groups (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15 each): C (control)\u2014no disinfection; AC (acai)\u2014acai photosensitizer application; AC + BL (acai + laser)\u2014acai photosensitizer application and irradiation with low-intensity blue laser diode (Therapy); and BL (laser)\u2014low-intensity blue laser diode (Therapy) application. All carious tissue was collected post-protocol application. Total viable bacterial count was determined after 2 days of incubation. Micro-computed tomography was used for qualitative analysis of carious lesions through observation of a carious tooth (control group). Scanning electron microscopy (SEM) was used for qualitative analysis of carious tissue disinfection using different protocols. Results were analyzed using the Kruskal\u2013Wallis test (Student\u2013Newman\u2013Keuls).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The cariogenic challenge produced a carious lesion measuring 17.14875 mm\n                      <jats:sup>3<\/jats:sup>\n                      , located in deep dentin close to the pulp. The AC + BL group showed the most significant reduction in\n                      <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                      count (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), followed by the AC group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0055). The BL group showed no significant reduction in\n                      <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                      count (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.2122). SEM analysis showed that AC + BL promoted dentin disinfection, with exposed dentinal tubules. The percentage reduction in\n                      <jats:italic toggle=\"yes\">S. mutans<\/jats:italic>\n                      count was: BL (35.75%), AC (63.41%), and AC + BL (92.68%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The AC + BL group showed significantly better results than the AC group alone. The acai photosensitizer, with or without antimicrobial photodynamic therapy, is indicated for carious dentin disinfection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785478261415718","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T11:49:13Z","timestamp":1770637753000},"page":"293-301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Use of Acai (\n                    <i>Euterpe oleracea<\/i>\n                    Martius) for Carious Dentin Disinfection, Combined or Not with Antimicrobial Photodynamic Therapy"],"prefix":"10.1177","volume":"44","author":[{"given":"Maria Clara","family":"de Assis","sequence":"first","affiliation":[{"name":"Department of Dentistry, Pontif\u00edcia Universidade Cat\u00f3lica de Campinas, Campinas, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Elias","family":"Arana-Chavez","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Oral Biology, School of Dentistry, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila Gonzales Freire","family":"Gusukuma","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio Luiz","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Postgraduate Program in Health Sciences, Pontif\u00edcia Universidade Cat\u00f3lica de Campinas, Campinas, SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1815"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2019.4736"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003808.pub3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2018.1444201"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077770"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.118393"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007840050062"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1093"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2013.05.010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2006.01.022"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1020995"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/824538"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1088\/1054-660X\/26\/12\/123001"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2013.811861"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.102718"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2590-x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03300-6"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.13172\/2054-2526-1-1-946"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.3611009"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0562-2"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2014.3776"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2018.4571"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1039\/c5pp00132c"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411565"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph15060767"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1039\/c9pp00375d"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101562"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2021.15"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00096"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2015.990573"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.9767\/bcrec.16.1.10314.161-169"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111959"},{"issue":"3","key":"e_1_3_3_34_2","first-page":"349","article-title":"Antioxidant and antimicrobial activities of propolis and a\u00e7ai (Euterpe oleracea Mart) extracts","volume":"32","author":"Gon\u00e7alves GMS","year":"2011","unstructured":"Gon\u00e7alves GMS, , Santos NP, , Srebernich SM. 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