{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:12:41Z","timestamp":1778069561033,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Assess clinical efficacy of photodynamic therapy (PDT) combined with periodontal regenerative surgery (PTR) in severe periodontitis, focusing on gingival thickness (GT), inflammatory markers, and bone repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixty patients were randomized to Combination (PDT + PTR) or Control (PTR alone) groups. PDT utilized 660 nm laser with methylene blue. Outcomes included probing depth (PD), clinical attachment loss (CAL), bleeding on probing (BOP), keratinized tissue width (KTW), GT, cone-beam computed tomography bone parameters, and gingival crevicular fluid cytokines (IL-1\u03b2, TNF-\u03b1, PGE2, MMP-8) at 3\/6\/12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At 12 months, Combination group showed superior PD reduction (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05), CAL gain (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05), lower BOP (16.67% vs. 43.33%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05), increased KTW\/GT, and enhanced bone density\/defect filling versus Control. Inflammatory markers were significantly reduced at 3 months (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). Three-wall defects exhibited better CAL\/GT outcomes than two-wall defects (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The combined PDT and PTR therapy demonstrated significant improvements in key clinical parameters, reduced inflammatory biomarkers, and enhanced radiographic bone fill in severe periodontitis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785478261424556","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:03:53Z","timestamp":1774937033000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Efficacy of Adjunctive Photodynamic Therapy with Periodontal Regenerative Surgery in Severe Periodontitis: A Randomized Controlled Trial on Gingival Thickness Remodeling and Inflammatory Cytokine Modulation"],"prefix":"10.1177","volume":"44","author":[{"given":"Dahai","family":"Huang","sequence":"first","affiliation":[{"name":"Center for Dental Medicine, The Affiliated Hospital of Yunnan University, Kunming, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine, The Affiliated Hospital of Yunnan University, Kunming, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine, The Affiliated Hospital of Yunnan University, Kunming, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13337"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12630"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-022-04127-9"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.34172\/japid.2022.008"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.2023.2199242"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103494"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13236"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103842"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12946"},{"issue":"5","key":"e_1_3_4_11_2","first-page":"59","article-title":"Antimicrobial efficacy of photodynamic therapy (PDT) in periodontitis and peri-implantitis: A systematic review","volume":"34","author":"Lopez MA","year":"2020","unstructured":"Lopez MA, , Passarelli PC, , Marra M, et al. Antimicrobial efficacy of photodynamic therapy (PDT) in periodontitis and peri-implantitis: A systematic review. J Biol Regul Homeost Agents, 2020; 34(5 Suppl. 3):59\u201365 Technology in Medicine.","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201024666230720104516"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010093"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01505-z"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/app13137647"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1002\/JPER.18-0006","article-title":"Staging and grading of periodontitis: Framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti MS","year":"2018","unstructured":"Tonetti MS, , Greenwell H, , Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. 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Adjunctive antimicrobial photodynamic therapy for treating periodontal and Peri-implant diseases. Cochrane Database Syst Rev, 2024; 2024(8):CD011778.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2022.7157"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052721"},{"issue":"10","key":"e_1_3_4_33_2","first-page":"e70929","article-title":"Comparative analysis of thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) levels in the gingival crevicular fluid (GCF) of diabetic patients with chronic periodontitis: An enzyme immunoassay study","volume":"16","author":"Mahale AY","year":"2024","unstructured":"Mahale AY, , Agarwal S, , Bansal R, et al. 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