{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:56:00Z","timestamp":1790848560820,"version":"4.1.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Horizontal Project of Industry-Education Integration","award":["KH54429301"],"award-info":[{"award-number":["KH54429301"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) is a leading cause of dementia in older adults, and effective and widely applicable treatment options remain limited. Photobiomodulation (PBM) has shown promise for AD. However, reported estimates of the delivered dose after transcranial propagation vary widely, limiting translation from animal models to clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Building on our team\u2019s prior clinical findings, this study evaluated whether an 810 nm\/10 Hz pulsed PBM regimen improves cognitive performance and reduces A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      burden in APP\/PS1 mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      APP\/PS1 mice received PBM using an 810 nm LED pulsed at 10 Hz. Irradiation was delivered for 540 sec\/day, 6 days\/week, for 7 weeks, with a scalp-surface power density of 0.025 W\/cm\n                      <jats:sup>2<\/jats:sup>\n                      and an energy density of 13.5 J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      . Cognitive function was evaluated using the Morris water maze, and A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      burden was quantified by immunofluorescence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Cortical and hippocampal A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      plaque burden was reduced,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01. Exploratory correlation analyses suggested an association between hippocampal A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      plaque number and reversal-learning performance in the histological subset,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02. The microglia-A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      colocalization ratio increased by 7.53%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03, indicating enhanced spatial association between microglia and A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      after PBM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings support further evaluation of this 810 nm\/10 Hz pulsed PBM regimen in AD mouse models and highlight the value of standardized PBM parameter reporting in preclinical studies.<\/jats:p>\n                  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Medical Devices, Ministry of Industry and Information Technology, Beijing, China."},{"name":"National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiting","family":"Qiao","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering, Beihang University, Beijing, China."},{"name":"Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beihang University, Beijing, China."},{"name":"Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, Beijing, China."},{"name":"National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Lv","sequence":"additional","affiliation":[{"name":"Rehabilitation Hospital Affiliated to National Rehabilitation Assistive Devices Research Center, Beijing, China."},{"name":"Key Laboratory of Assistive Technology for Rehabilitation of Elderly Dysfunction, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering, Beihang University, Beijing, China."},{"name":"Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Beihang University, Beijing, China."},{"name":"Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, Beijing, China."},{"name":"National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of 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