{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:04:53Z","timestamp":1785546293976,"version":"3.56.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"crossref","award":["Grant No. TSGH-D-111106"],"award-info":[{"award-number":["Grant No. TSGH-D-111106"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the clinical efficacy of intravenous laser irradiation of blood (ILIB) therapy as an adjunct treatment for patients with ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Despite the diverse medical applications of ILIB, there was no strong evidence on the efficacy of ILIB for improving the clinical outcomes of ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 22 patients with ischemic stroke were randomly assigned to either the ILIB or the control group. The ILIB group received intravenous laser therapy, whereas the control group received the same intervention but without the output power. The after outcome measures were assessed at baseline and at 3 days, 1 month, and 3 months post intervention: National Institute of Health Stroke Scale score, modified Rankin Scale score, Stroke Impact Scale (SIS) score, Fugl-Meyer assessment-Motor Function (FMA-MF) score, and 6-minute walking test (6-MWT) performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 10 and 12 participants were randomized to the ILIB and control groups, respectively. Compared with the control group, the ILIB group showed significantly better SIS scores at the 3-month follow-up (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.019), significantly higher FMA-MF scores at the 3-day and 3-month follow-ups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.003 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.022), and significantly better 6-MWT performance at the 3-day follow-up (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>ILIB therapy provided short-term improvements in functional outcomes, including SIS, FMA-MF scores, and 6-MWT, in patients with ischemic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785478261465534","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:59:02Z","timestamp":1782784742000},"page":"513-520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Intravascular Laser Irradiation of Blood in Functional Outcomes of Ischemic Stroke Patients: A Double-Blind Randomized Control Pilot Study"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6771-9330","authenticated-orcid":false,"given":"Yu-Chi","family":"Su","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, College of Medicine, National Defense Medical University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta-Chung","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, College of Medicine, National Defense Medical University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, College of Medicine, National Defense Medical University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, College of Medicine, National Defense Medical University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ya","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, College of Medicine, National Defense Medical University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Ting","family":"Pan","sequence":"additional","affiliation":[{"name":"Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, National Defense Medical University, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, College of Medicine, National Defense Medical University, Taipei, Taiwan."},{"name":"Department of Rehabilitation, Taipei City Hospital, Yangming Branch, Taipei, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113000"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0118-8"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01401-0"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1106"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200708133912"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60325-5"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.63.5.621"},{"issue":"6","key":"e_1_3_3_10_1","first-page":"Cd000425","article-title":"Speech and language therapy for aphasia following stroke","volume":"2016","author":"Brady MC","year":"2016","unstructured":"9.Brady MC, , Kelly H, , Godwin J, , Enderby P, , Campbell P. 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