{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:05:14Z","timestamp":1785546314533,"version":"3.56.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">\n                      <jats:bold>Objective:<\/jats:bold>\n                    <\/jats:italic>\n                    Ultraviolet B (UVB) irradiation primarily causes skin photoaging by disrupting redox homeostasis, triggering inflammatory responses, and accelerating collagen loss.\n                    <jats:italic toggle=\"yes\">Sarcandra glabra<\/jats:italic>\n                    extract (SGE) is a traditional Chinese herbal extract rich in bioactive compounds and exhibits potential anti-inflammatory and antioxidant activities.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>This study used a zebrafish model to investigate the protective effect and molecular mechanism of SGE against UVB-induced photodamage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>\n                      High-performance liquid chromatography (HPLC) analysis identified rosmarinic acid as the main bioactive component in SGE, with a mass fraction of 4.67%, while safety evaluations showed that it showed no significant toxicity toward zebrafish at concentrations of 10 \u03bcg\/mL or lower. After establishing the UVB zebrafish photodamage model, different SGE concentrations were administered, which alleviated UVB-induced mortality, repaired caudal fin damage, reduced the apoptosis rate, and decreased the intracellular reactive oxygen species levels in zebrafish in a dose-dependent manner. Further, SGE significantly enhanced the superoxide dismutase, catalase, and glutathione peroxidase activity, while decreasing the malondialdehyde content in the UVB-irradiated zebrafish, effectively mitigating oxidative stress injury. At the molecular level, SGE significantly inhibited the abnormal upregulation of the\n                      <jats:italic toggle=\"yes\">cox-2<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">IL-1\u03b2<\/jats:italic>\n                      inflammation-related genes induced by UVB. It also promoted the transcriptional expression of the\n                      <jats:italic toggle=\"yes\">col1a1a<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">col1a1b<\/jats:italic>\n                      type I collagen-encoding genes, breaking the detrimental oxidative stress-inflammation-collagen loss cycle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>The findings of this study indicate that SGE possesses excellent anti-inflammatory, antioxidant, and anti-UVB photodamage properties and can be used as a natural bioactive ingredient in skincare products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/25785478261467216","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:20:49Z","timestamp":1784341249000},"page":"521-530","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Protective Effect and Underlying Mechanisms of\n                    <i>Sarcandra glabra<\/i>\n                    Extract Against UVB-Induced Photodamage in Zebrafish"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9843-9821","authenticated-orcid":false,"given":"Yurun","family":"Zhang","sequence":"first","affiliation":[{"name":"National Center for Standardization Technology Evaluation, State Administration for Market Regulation, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadi","family":"Yu","sequence":"additional","affiliation":[{"name":"National Center for Standardization Technology Evaluation, State Administration for Market Regulation, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28072929"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8255"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1939263"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15902"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04475-3"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.11.164"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b05125"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155981"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118131"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120002"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1931023"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.10.016"},{"key":"e_1_3_2_14_1","first-page":"69","volume-title":"Progress in Molecular Biology and Translational Science","author":"Sharma P","year":"2021","unstructured":"13.Sharma P, , Sharma BS, , Verma RJ. Chapter Three\u2014CRISPR-based genome editing of zebrafish. In: Progress in Molecular Biology and Translational Science. (Singh V., Ed). Academic Press: London, UK; 2021; Volume 180, pp. 69\u201384."},{"issue":"14","key":"e_1_3_2_15_1","first-page":"2343","article-title":"[Simultaneous determination of rosmarinic acid, oridonin and chrysoplenetin in Isodon rubescens by HPLC]","volume":"38","author":"Yuan XL","year":"2013","unstructured":"14.Yuan XL, , Yan LH, , Zhang QW, , Wang ZM. [Simultaneous determination of rosmarinic acid, oridonin and chrysoplenetin in Isodon rubescens by HPLC]. Zhongguo Zhong Yao Za Zhi 2013;38(14):2343\u20132347.","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"7","key":"e_1_3_2_16_1","first-page":"1417","article-title":"Simultaneous determination of fumaric acid, isofraxidin and rosmarinic acid in Sarcandra glabra by HPLC","volume":"31","author":"Eng JW","year":"2011","unstructured":"15.Eng JW, et al. Simultaneous determination of fumaric acid, isofraxidin and rosmarinic acid in Sarcandra glabra by HPLC. Chin J Pharm Anal 2011;31(7):1417\u20131419; doi: 10.16155\/j.0254-1793.2011.07.018","journal-title":"Chin J Pharm Anal"},{"issue":"3","key":"e_1_3_2_17_1","first-page":"68","article-title":"Comparative study on the content of isofraxidin in Sarcandra glabra by different extraction methods","volume":"31","author":"Hong J","year":"2019","unstructured":"16.Hong J. Comparative study on the content of isofraxidin in Sarcandra glabra by different extraction methods. Strait Pharm J 2019;31(3):68\u201370.","journal-title":"Strait Pharm J"},{"issue":"10","key":"e_1_3_2_18_1","first-page":"80","article-title":"Effects of different extraction methods on the content of isofraxidin in Sarcandra glabra","volume":"30","author":"Lin G","year":"2018","unstructured":"17.Lin G, , Huang QW. Effects of different extraction methods on the content of isofraxidin in Sarcandra glabra. Strait Pharm J 2018;30(10):80\u201382.","journal-title":"Strait Pharm J"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03609-x"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122442"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155676"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13081002"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122312"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010011"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-022-00511-3"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112987"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156008"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.03.200"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-19821-8"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14070766"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2023.115245"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13040483"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.05.074"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0180"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5fo02981c"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112934"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14050551"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1566287"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.10.005"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115262"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S446090"}],"container-title":["Photobiomodulation, Photomedicine, and Laser Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25785478261467216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/25785478261467216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/25785478261467216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:17:38Z","timestamp":1785539858000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/25785478261467216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/25785478261467216"],"URL":"https:\/\/doi.org\/10.1177\/25785478261467216","relation":{},"ISSN":["2578-5478","2578-5478"],"issn-type":[{"value":"2578-5478","type":"print"},{"value":"2578-5478","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]}}}