{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:57:01Z","timestamp":1787950621354,"version":"build-2784847793"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Gastroenterol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with Peutz\u2013Jeghers syndrome develop hamartomatous polyps in the small bowel, possibly causing anemia, intussusception, and obstruction. We aimed to evaluate the impact of an enteroscopy-based approach, including both device-assisted and intraoperative enteroscopy, on the reduction of the polyp burden in a cohort of adult Peutz\u2013Jeghers syndrome patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>A retrospective study was conducted at Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza in Turin, Italy. Consecutive Peutz\u2013Jeghers syndrome patients eligible for device-assisted or intraoperative enteroscopy, between January 2003 and November 2019, were included. Enteroscopy technical issues and complications were recorded. At the time of index enteroscopy, the patients\u2019 clinical records were retrospectively reviewed, and clinical data were recorded until November 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 24 patients were included. Before inclusion, 16\/24 patients (66.7%) underwent small bowel surgery for polyp-related complications, 13 of which (81.2%) in an emergent setting. Two patients had a history of small bowel neoplasms. During the timeframe, 47 device-assisted enteroscopies and 9 intraoperative enteroscopies were performed, and 247 small bowel polyps were endoscopically removed. The overall complication rate was 12.8% (8.5% for device-assisted enteroscopy, 22.2% for intraoperative enteroscopy). The median observation time was 108\u2009months: in this timeframe, two patients developed small bowel polyp-related complications requiring emergent surgery. No patients developed small bowel cancer, but nine extra-gastrointestinal neoplasms were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An enteroscopy-based approach appears to be well tolerated and effective in decreasing polyp-related complications in Peutz\u2013Jeghers syndrome patients, thus reducing the need for emergent surgery. Although the prevention of small bowel polyp-related complications remains the main goal in these patients, the high incidence of extra-gastrointestinal neoplasms appears to be a rising issue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2631774520919369","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T04:51:36Z","timestamp":1589431896000},"page":"263177452091936","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and efficacy of an enteroscopy-based approach in reducing the polyp burden in patients with Peutz\u2013Jeghers syndrome: experience from a tertiary referral center"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8793-5890","authenticated-orcid":false,"given":"Pablo","family":"Cortegoso Valdivia","sequence":"first","affiliation":[{"name":"University Division of Gastroenterology, Department of Medical Sciences, City of Health and Science University Hospital, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Rondonotti","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Valduce Hospital, Como, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6151-0395","authenticated-orcid":false,"given":"Marco","family":"Pennazio","sequence":"additional","affiliation":[{"name":"University Division of Gastroenterology, Department of Medical Sciences, City of Health and Science University Hospital, Via Cavour 31, 10123 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"bibr1-2631774520919369","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.11.005"},{"key":"bibr2-2631774520919369","first-page":"134","volume":"10","author":"Peutz J.","year":"1921","journal-title":"Nederl 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