{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:17:40Z","timestamp":1787019460821,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med Insights Gastroenterol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims:<\/jats:title>\n                    <jats:p>\n                      Endoscopic assessment of the regular arrangement of collecting venules (RAC) is a simple and reliable tool for predicting the absence of\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      ) infection in the stomach, particularly in Asian populations. While initial studies in Western countries have yielded similar findings, RAC assessment has not yet been widely adopted in these settings. This study aims to evaluate the diagnostic accuracy of RAC in determining\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      status in a non-Asian population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This prospective, multicenter study was conducted in 12 hospitals across non-Asian countries. Patients with no history of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection or eradication were included, regardless of proton pump inhibitor (PPI) use. All participants underwent high-definition upper endoscopy without magnification or virtual chromoendoscopy. Endoscopists were trained using a 20-image test to identify the RAC pattern.\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      status was determined by histology and\/or immunohistochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 648 patients were included, with an\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection prevalence of 34.7%. The RAC+ pattern was observed in 31.5% of patients, with no significant differences between those receiving PPI treatment and those who were not (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.55). Absence of pathological endoscopic findings was significantly associated with a RAC+ pattern (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01). The sensitivity and negative predictive value (NPV) of RAC+ for ruling out\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection were 0.97 (95% CI: 0.94\u20130.99), reaching 1.00 when discordant images were reviewed by a blinded expert endoscopist. No significant differences in sensitivity or NPV were found between PPI users and non-users, or between regions with high and low\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      prevalence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The presence of the RAC pattern along the minor gastric curvature, as assessed with white-light endoscopy, accurately identifies patients without\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      infection in non-Asian countries, regardless of PPI use.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26317745251387183","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:30:37Z","timestamp":1764311437000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Regular arrangement of collecting venules as a predictor of\n                    <i>Helicobacter pylori<\/i>\n                    absence using white-light endoscopy: a multicenter prospective study outside Asia"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-8704","authenticated-orcid":false,"given":"Rodrigo","family":"Garc\u00e9s-Duran","sequence":"first","affiliation":[{"name":"Cliniques Universitaires Saint Luc, H.UNI, Hippocrate 10, Brussels 1200, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Llach","sequence":"additional","affiliation":[{"name":"Hospital Clinic Barcelona, Facultat de Medicina i 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Brussel, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bornschein","sequence":"additional","affiliation":[{"name":"Translational Immune Discovery Unit, Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM), Radcliffe Department of Medicine, University of Oxford, Oxford, UK"},{"name":"Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre H.","family":"Deprez","sequence":"additional","affiliation":[{"name":"Cliniques Universitaires Saint Luc, H.UNI, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masa Cavlina","family":"Sevo","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Realdon","sequence":"additional","affiliation":[{"name":"Centro di Rifermento Oncologico, Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8883-1121","authenticated-orcid":false,"given":"Ivan","family":"Lyutakov","sequence":"additional","affiliation":[{"name":"Universitary Hospital \u2018TsaritsaYoanna \u2013 ISUL\u2019, Medical University Sofia, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna","family":"Ebigbo","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Universitary Hospital of Augsburg, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innocent","family":"Francis","sequence":"additional","affiliation":[{"name":"Groote Schuur Hospital, Cape Town, South 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