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He had remote history of cutaneous squamous cell carcinoma with no sign of recurrence, and his CLL\/SLL was thought to be in remission. Computed tomography showed mild splenomegaly and multifocal lymphadenopathy including a 3-cm left neck mass. Biopsy of the left neck mass showed CLL\/SLL with associated histiocytic sarcoma. Flow cytometry demonstrated a B cell neoplasm with CLL\/SLL phenotype. Despite radiation therapy, he expired 3\u2009months after presentation. Two similar cases (CLL\/SLL and histiocytic sarcoma, follicular lymphoma and Langerhans cell sarcoma) from another institution are also illustrated. The pathological features of combined tumors in lymphoid neoplasms, a general framework to the work-up to determine interrelatedness of tumor components, and the clinical relevance are discussed.<\/jats:p>","DOI":"10.1177\/2632010x19878410","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T09:26:16Z","timestamp":1569835576000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Combined Tumors in Hematolymphoid Neoplasms: Case Series of Histiocytic and Langerhans Cell Sarcomas Arising From Low-Grade B-Cell Lymphoma"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5631-5381","authenticated-orcid":false,"given":"Stephanie L","family":"Skala","sequence":"first","affiliation":[{"name":"Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing C","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Stumph","sequence":"additional","affiliation":[{"name":"Michigan Pathology Specialists, Spectrum Health, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R","family":"Macon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances R","family":"Quinones","sequence":"additional","affiliation":[{"name":"Michigan Pathology Specialists, Spectrum Health, Grand Rapids, MI, 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