{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:04:49Z","timestamp":1777881889092,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdPathol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Pigmented lesions of the oral mucosa encompass several benign and malignant conditions that may be a matter of concern under both clinical and histopathological views. We reported a case of a 62-year-old woman, presenting with an asymptomatic, deeply pigmented lesion on the soft palate. On examination, it appeared asymmetrical, with irregular borders and an area of ulceration. A biopsy, taken to rule out melanoma, revealed a pigmented carcinoma in situ. Throughout the tumor thickness, numerous interspersed melanocytes were found that did not extend to neighboring epithelium. These were large, richly dendritic, and presented abundance of melanin granules and small nuclei. Mild melanin incontinence was found. Scanty transfer of pigment to dysplastic epithelial cells was found through Fontana Masson staining. On immunohistochemical analyses, there were pancytokeratin-stained tumor epithelial cells; increased cell proliferation throughout the entire thickness of the tumor was emphasized by Ki-67 immunomarking. P16 was negative. The dendritic cells were selectively stained for S-100, HMB45 and Melan A. Wide spectrum in situ hybridization for human papillomavirus (HPV) was negative. Unfortunately, following diagnosis, the patient refused any treatment option. Pigmented squamous cell carcinoma with melanocyte colonization must be taken into account in the differential diagnosis of pigmented lesions of the oral cavity.<\/jats:p>","DOI":"10.1177\/2632010x211009819","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:01:17Z","timestamp":1618963277000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Uncommon Pigmented Carcinoma In Situ: Case Report and Brief Review"],"prefix":"10.1177","volume":"14","author":[{"given":"Andresa Borges","family":"Soares","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, S\u00e3o Leopoldo Mandic Institute and Research Center, Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Cavalcanti","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, S\u00e3o Leopoldo Mandic Institute and Research Center, Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Passador-Santos","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, S\u00e3o Leopoldo Mandic Institute and Research Center, Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Alexandre","family":"Thomaz","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Universidade S\u00e3o Francisco, Bragan\u00e7a Paulista, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre Luis Santana","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Unisanta\u2014Universidade Santa Cecilia, Santos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Claudio","family":"Mautoni","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Unisanta\u2014Universidade Santa Cecilia, Santos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Fantelli","family":"Stelini","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Leticia","family":"Cintra","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, State University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"bibr1-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-007-0014-5"},{"key":"bibr2-2632010X211009819","volume-title":"WHO Classification of Head and Neck Tumours (IARC WHO Classification of Tumours)","author":"El-Naggar AK","year":"2017","edition":"4"},{"key":"bibr3-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01319.x"},{"key":"bibr4-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.03.048"},{"key":"bibr5-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.01.230"},{"key":"bibr6-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00587.x"},{"key":"bibr7-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(81)90365-0"},{"key":"bibr8-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318156d756"},{"key":"bibr9-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(74)80011-6"},{"key":"bibr10-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd1959.23.1"},{"key":"bibr11-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930280105"},{"key":"bibr12-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb00775.x"},{"key":"bibr13-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-4220(06)80108-8"},{"key":"bibr14-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1177\/1066896908315747"},{"key":"bibr15-2632010X211009819","volume":"9","author":"Martins F","year":"2017","journal-title":"J Clin Exp Dent"},{"key":"bibr16-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027002093.x"},{"key":"bibr17-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02934.x"},{"key":"bibr18-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199812000-00006"},{"key":"bibr19-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027008381.x"},{"key":"bibr20-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.04.006"},{"key":"bibr21-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e84652"},{"key":"bibr22-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.08.001"},{"key":"bibr23-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-010-0200-8"},{"key":"bibr24-2632010X211009819","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.102514"}],"container-title":["Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2632010X211009819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2632010X211009819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2632010X211009819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:56:12Z","timestamp":1777596972000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2632010X211009819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":24,"alternative-id":["10.1177\/2632010X211009819"],"URL":"https:\/\/doi.org\/10.1177\/2632010x211009819","relation":{},"ISSN":["2632-010X","2632-010X"],"issn-type":[{"value":"2632-010X","type":"print"},{"value":"2632-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"2632010X211009819"}}