{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:04:53Z","timestamp":1777881893450,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdPathol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Lambert-Eaton syndrome is a rare paraneoplastic disorder of the neuromuscular junction, characterized by impaired release of acetylcholine, which causes proximal muscle weakness, depressed tendon reflexes, and autonomic changes. Most cases of Lambert-Eaton syndrome present in small-cell lung carcinoma, and only a few cases have been reported in other lung subtypes. Herein, we report a case of 69\u2009years old male patient with Lambert-Eaton syndrome as a rare association with a pulmonary large-cell neuroendocrine carcinoma, which presented 5\u2009months before neoplasm diagnosis. A lobectomy was auspiciously performed. A review of the literature is also presented.<\/jats:p>","DOI":"10.1177\/2632010x211051741","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T06:47:08Z","timestamp":1633934828000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulmonary Large Cell Neuroendocrine Carcinoma Associated With Lambert-Eaton Syndrome"],"prefix":"10.1177","volume":"14","author":[{"given":"Pamela","family":"Hernandez-Arriaga","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-1541","authenticated-orcid":false,"given":"Mauricio","family":"Gonzalez-Urquijo","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Fernando","family":"L\u00f3pez Altamirano","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-3259","authenticated-orcid":false,"given":"Bryan","family":"Vaca-Cartagena","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Vergil-Vargas","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviano","family":"Rios-Pascual","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Eduardo","family":"Perez-Saucedo","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Sep\u00falveda-Malec","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"bibr1-2632010X211051741","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1957.02970480021005"},{"key":"bibr2-2632010X211051741","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70245-9"},{"key":"bibr3-2632010X211051741","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21032"},{"key":"bibr4-2632010X211051741","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199411000-00030"},{"key":"bibr5-2632010X211051741","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.7.1490"},{"key":"bibr6-2632010X211051741","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2016.02.001"},{"key":"bibr7-2632010X211051741","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v5.i3.197"},{"key":"bibr8-2632010X211051741","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.3.577"}],"container-title":["Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2632010X211051741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2632010X211051741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2632010X211051741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:56:18Z","timestamp":1777596978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2632010X211051741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":8,"alternative-id":["10.1177\/2632010X211051741"],"URL":"https:\/\/doi.org\/10.1177\/2632010x211051741","relation":{},"ISSN":["2632-010X","2632-010X"],"issn-type":[{"value":"2632-010X","type":"print"},{"value":"2632-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"2632010X211051741"}}