{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:35:51Z","timestamp":1792438551767,"version":"4.5.0"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdPathol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Coxiella burnetii is an obligate intracellular bacterium that causes the zoonotic infectious disease, Q fever. The common clinical presentation is fever, hepatitis, and pneumonia; laboratory examination could reveal pancytopenia, elevated liver enzymes. In bone marrow, many fibrin ring granulomas, also known as \u201cDoughnut\u201d granulomas can be seen and suggest the diagnosis of Q fever. However, these bone marrow granulomas can also be presented in infectious diseases by other pathogens such as EBV, CMV, and HBV; therefore, other serology or PCR\u2014based tests are needed to confirm the diagnosis of Q fever. We report the first case of acute Q fever in Vietnam, presented as a fever of unknown origin with hepatitis in a 53-year-old male patient. A bone marrow biopsy was performed and showed various fibrin ring granulomas; therefore, Coxiella was suspected and the diagnosis was confirmed by PCR. Some infectious diseases can cause specific changes in the bone marrow, such as Doughnut granulomas in Q fever. These features can help direct the diagnosis and decide earlier treatment for the patient.<\/jats:p>","DOI":"10.1177\/2632010x221096397","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T19:58:17Z","timestamp":1652903897000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The First Case of Coxiella Burnetti Infection Detected Through Bone Marrow Biopsy in Vietnam"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1162-8066","authenticated-orcid":false,"given":"Do","family":"Thi Vinh An","sequence":"first","affiliation":[{"name":"The Center of Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bui","family":"Thi Viet Ha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao","family":"Xuan Co","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu","family":"Minh Tam","sequence":"additional","affiliation":[{"name":"The Center of Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Thi Diem Tuyet","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu","family":"Van Truong","sequence":"additional","affiliation":[{"name":"The Center of Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"bibr1-2632010X221096397","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00042-10"},{"key":"bibr2-2632010X221096397","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00045-16"},{"key":"bibr3-2632010X221096397","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/71.1.117"},{"key":"bibr4-2632010X221096397","doi-asserted-by":"publisher","DOI":"10.1177\/1066896906299074"},{"key":"bibr5-2632010X221096397","doi-asserted-by":"publisher","DOI":"10.2807\/ese.18.08.20407-en"},{"key":"bibr6-2632010X221096397","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp077"},{"key":"bibr7-2632010X221096397","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2012.46.1.10"},{"key":"bibr8-2632010X221096397","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2011.00876.x"},{"key":"bibr9-2632010X221096397","unstructured":"Herndon G, Rogers HJ. Multiple \u201cdoughnut\u201d granulomas in Coxiella burnetii infection (Q fever). 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