{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:05:06Z","timestamp":1777881906413,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdPathol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Splenic lymphoma may be primary or secondary. Primary splenic lymphoma\u2019s are rare and usually of follicular cell origin representing &lt;1% of Non-Hodgkin\u2019s Lymphoma\u2019s. Most are secondary with 35% representing Marginal Cell sub-type with the rest being Diffuse Large B-Cell Lymphoma\u2019s. Unlike the uniformly aggressive clinical course of Diffuse Large B-Cell Lymphoma\u2019s, biological behavior of Primary Splenic CD10-Positive Small B-Cell Lymphoma\/Follicular Lymphoma remains less well defined. We present here a solitary splenic mass confirmed as Primary Splenic CD10-Positive Small B-Cell Lymphoma\/Follicular Lymphoma after a diagnostic splenectomy. Biopsy revealed monomorphic small lymphoid cells with low grade mitotic activity. Flow cytometry showed a lambda restricted population of B-Cells displaying dim CD19 and CD10. The cells were negative for CD5, CD11c, and CD103. FISH was negative for IGH\/BCL2 fusion unlike nodal Follicular Lymphoma\u2019s which are usually positive for this translocation. Evidence from this case and a review of literature support the finding that Primary Splenic CD10-Positive Small B-Cell Lymphoma\/Follicular Lymphoma is less likely to have the classic IGH-BCL2 fusion and the associated chromosomal 14;18 translocation. This profile is associated with less aggressive clinical behavior even when histopathology represents a high-grade pattern. In such cases splenectomy alone is adequate for localized disease when negative for IGH\/BCL2 fusion regardless of histological grade.<\/jats:p>","DOI":"10.1177\/2632010x221129242","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T08:56:39Z","timestamp":1666688199000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["IGH\/BCL2 Status Better Predicts Clinico-Pathological Behavior in Primary Splenic Follicular Lymphoma than Histological Grade and Other Molecular Markers"],"prefix":"10.1177","volume":"15","author":[{"given":"Cherian","family":"Verghese","sequence":"first","affiliation":[{"name":"Division of Hematology & Oncology, University of Missouri, Columbia, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Toledo College of Medicine, 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