{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:57:31Z","timestamp":1779400651411,"version":"3.53.1"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdPathol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aim\/objective:<\/jats:title>\n                    <jats:p>Assess agreement between light microscopy and direct immunofluorescence (DIF) for histopathologic evaluation of oral lichen planus (OLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Records evaluated included 60 OLP, 16 lichenoid mucositis (LM), and 56 non-OLP\/non-LM cases. Cases had both light microscopic and DIF evaluations. Histopathologic parameters of OLP included: (1) hydropic degeneration of the basal cell layer, (2) band-like lymphocytic infiltrate immediately subjacent to the epithelium, and (3) presence of Civatte bodies. Two calibrated examiners independently assessed light microscopic features. Examiners reviewed cases with discordant diagnoses to determine a consensus diagnosis. Intra-rater reliability (IRR), sensitivity, specificity, positive, and negative predictive values (PPV and NPV) were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 132 patients, 72.7% were female, average age 61.9 (SD\u2009=\u200913.8). Most common sites were gingiva (37.9%), buccal mucosa (37.1%), and tongue (7.6%). IRR was 0.74 (95% CI: 0.40, 1.00) for the consensus diagnosis and 0.73 (95% CI: 0.39, 1.00) and 0.34 (95% CI: \u22120.03, 0.72) for the 2 examiners. Comparing consensus and definitive diagnoses: sensitivity of light microscopy: 0.32 (95% CI: 0.20, 0.45); specificity: 0.88 (95% CI: 0.78, 0.94); PPV: 0.68 (95% CI: 0.48, 0.84), and NPV: 0.61 (95% CI: 0.51, 0.70).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Light microscopy alone is not a viable alternative to adjunctive DIF for diagnosis of OLP lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2632010x231197111","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T04:44:54Z","timestamp":1694580294000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing the Agreement of Light Microscopic Evaluation of Oral Lichen Planus Lesions With Associated Direct Immunofluorescence Evaluation"],"prefix":"10.1177","volume":"16","author":[{"given":"Blake T","family":"Hansen","sequence":"first","affiliation":[{"name":"Alumnus, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B","family":"Payne","sequence":"additional","affiliation":[{"name":"Department of Surgical Specialties, F. Gene and Rosemary Dixon Endowed Chair in Dentistry, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, USA"},{"name":"Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaeli K","family":"Samson","sequence":"additional","affiliation":[{"name":"College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Cruzan Center for Dental Research, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"bibr1-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"bibr2-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90422-6"},{"key":"bibr3-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090010501"},{"key":"bibr4-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(78)90383-3"},{"key":"bibr5-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.49.89"},{"key":"bibr6-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.11.001"},{"key":"bibr7-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13704"},{"key":"bibr8-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb06629.x"},{"key":"bibr9-2632010X231197111","first-page":"174","volume":"95","author":"Kilpi AM","year":"1987","journal-title":"Scand J Dent Res"},{"key":"bibr10-2632010X231197111","first-page":"1","volume":"84","author":"Kilpi A","year":"1988","journal-title":"Proc Finn Dent Soc"},{"key":"bibr11-2632010X231197111","first-page":"361","volume":"97","author":"Jungell P","year":"1989","journal-title":"Scand J Dent Res"},{"key":"bibr12-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00077.x"},{"key":"bibr13-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00142-5"},{"key":"bibr14-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90210-5"},{"key":"bibr15-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00305-6"},{"key":"bibr16-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120452"},{"key":"bibr17-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00139-8"},{"key":"bibr18-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12996"},{"key":"bibr19-2632010X231197111","volume":"9","author":"Buajeeb W","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"bibr20-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.05.004"},{"key":"bibr21-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02038.x"},{"key":"bibr22-2632010X231197111","doi-asserted-by":"publisher","DOI":"10.1007\/s40496-014-0022-y"}],"container-title":["Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2632010X231197111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2632010X231197111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2632010X231197111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:57:00Z","timestamp":1777597020000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2632010X231197111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":22,"alternative-id":["10.1177\/2632010X231197111"],"URL":"https:\/\/doi.org\/10.1177\/2632010x231197111","relation":{},"ISSN":["2632-010X","2632-010X"],"issn-type":[{"value":"2632-010X","type":"print"},{"value":"2632-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"2632010X231197111"}}