{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:43:01Z","timestamp":1793058181986,"version":"4.5.0"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdPathol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      The study was carried out to assess the effect of zinc supplementation on changes in calcium homeostasis, and parathyroid gland, bone, and skeletal muscle histology in rats exposed to subchronic oral glyphosate-based herbicide (GBH, GOBARA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) toxicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixty male Wistar rats in 6 equal groups (DW, Z, G1, G2, ZG1, ZG2) were used: DW and Z were given 2\u2009mL\/kg distilled water and 50\u2009mg\/kg of zinc chloride (2%), respectively; G1 and G2 received 187.5\u2009mg\/kg and 375\u2009mg\/kg of glyphosate (in GBH), respectively; ZG1 and ZG2 were pretreated with 50\u2009mg\/kg of zinc chloride before receiving glyphosate, 1\u2009hour later, at 187.5 and 375\u2009mg\/kg, respectively. Treatments were by gavage once daily for 16\u2009weeks. Serum calcium, vitamin D, and parathormone were estimated. Histopathological examination of parathyroid gland, femoral bone and biceps femoris muscle was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>GBH exposure caused significant ( P\u2009=\u2009.0038) decrease in serum calcium concentration in G1, significant ( P\u2009=\u2009.0337) decrease in serum vitamin D concentration in G1, significant increases in parathormone in G1 ( P\u2009=\u2009.0168) and G2 ( P\u2009=\u2009.0079) compared to DW. Significant ( P\u2009&gt;\u2009.05) changes did not occur in the other parameters of G2 compared to DW. Dose-dependent effect in GBH exposure was not observed after comparing G1 and G2. Necrotic changes occurred in parathyroid gland cells, osteocytes, and muscle cells in G1 and G2. In ZG1 and ZG2, significant ( P\u2009&gt;\u2009.05) variations in the parameters were not observed and tissue lesions were absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Subchronic GBH exposure impaired calcium homeostasis observed as hypocalcemia, hypovitaminemia D, and secondary hyperparathyroidism and caused tissue damage in parathyroid gland, bone, and muscle of rats and these were mitigated by zinc chloride pretreatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2632010x241265854","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:32:30Z","timestamp":1721971950000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Zinc Supplementation on Altered Calcium Homeostasis, Parathyroid Gland, Bone, and Skeletal Muscle Histology Induced by Subchronic Oral Exposure to Glyphosate-Based Herbicide (GOBARA\n                    <sup>\u00ae<\/sup>\n                    ) in Wistar Rats"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-1902","authenticated-orcid":false,"given":"Emmanuel Vandi","family":"Tizhe","sequence":"first","affiliation":[{"name":"Department of Veterinary Microbiology and Pathology, Faculty of Veterinary Medicine, University of Jos, Jos, Plateau State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikechukwu Onyebuchi","family":"Igbokwe","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine Onwu-Ibe","family":"Njokwu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Microbiology and Pathology, Faculty of 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