{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:40:11Z","timestamp":1780461611300,"version":"3.54.1"},"reference-count":94,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat\ufffdCare"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Nausea and vomiting are common experiences and are often dreaded more than pain. This review discusses blonanserin, mirtazapine, and isopropyl alcohol as antiemetics. Blonanserin, an atypical antipsychotic with a high affinity for dopamine D2 and D3 receptors and serotonin receptor 5-HT2A, has less of a risk of extrapyramidal adverse effects. Transdermal blonanserin, available in Korea, Japan, and China in a small number of trials, has improved nausea in patients not responding to standard antiemetics. Mirtazapine is a noradrenergic and specific serotonergic antidepressant that has been used for multiple symptoms besides depression. There is little evidence that mirtazapine improves anorexia or nausea in advanced cancer but is as effective as olanzapine in reducing chemotherapy-induced nausea and vomiting. Isopropyl alcohol aromatherapy has been successfully used in the emergency department for nausea and vomiting with an onset to benefit more rapidly than standard antiemetics. Isopropyl alcohol prep pads can be used for home-going antiemetic therapy and as a bridge to treating acute nausea until standard antiemetics take effect.<\/jats:p>","DOI":"10.1177\/26323524241257701","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T01:36:10Z","timestamp":1717724170000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel therapies for nausea and vomiting in advanced illness and supportive cancer care"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7903-3993","authenticated-orcid":false,"given":"Mellar P.","family":"Davis","sequence":"first","affiliation":[{"name":"Geisinger Commonwealth School of Medicine, 100 North Academy Avenue, Danville, PA 17822, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-029942"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.11.321"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.1052"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06437-w"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2016.08.001"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2017.1288214"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4404-8"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001545"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2023.0076"},{"key":"e_1_3_4_11_2","article-title":"Clinical assessment of weight gain with atypical antipsychotics \u2013 blonanserin vs amisulpride","volume":"9","author":"Deepak TS","year":"2015","unstructured":"Deepak TS, Raveesh BN, Parashivamurthy BM, et al. Clinical assessment of weight gain with atypical antipsychotics \u2013 blonanserin vs amisulpride. J Clin Diagn Res 2015; 9: FC07\u2013FC10.","journal-title":"J Clin Diagn Res"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2011.02213.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2010.02124.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2012.09.003"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2023.01.006"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2165\/11202620-000000000-00000"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00659-7"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-021-00361-3"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12057"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2021.110470"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0000000000000428"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1835"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2020.03.006"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S134340"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088049"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.06.005"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704608"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0834-1"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00692-6"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicines6030073"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00838.2020"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264386"},{"key":"e_1_3_4_33_2","first-page":"3541073","article-title":"A randomized controlled trial for prevention of postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: aprepitant\/dexamethasone vs. mirtazapine\/dexamethasone","volume":"2022","author":"Ashoor TM","year":"2022","unstructured":"Ashoor TM, Kassim DY, Esmat IM. A randomized controlled trial for prevention of postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: aprepitant\/dexamethasone vs. mirtazapine\/dexamethasone. Anesthesiol Res Pract 2022; 2022: 3541073.","journal-title":"Anesthesiol Res Pract"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-022-00494-2"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2018.11.006"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000656"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2013.07.016"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2010.06561.x"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000289636.09841.bc"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1381\/096089206778663634"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.4103\/IJPC.IJPC_17_17"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/1049909109345685"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.41.4.356"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2007.01778.x"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.05.002"},{"key":"e_1_3_4_46_2","first-page":"329","article-title":"[Effectiveness of mirtazapine for digestive symptoms in palliative care \u2013 retrospective study of 50 cases]","volume":"41","author":"Shibahara H","year":"2014","unstructured":"Shibahara H, Uematsu N, Imai E, et al. [Effectiveness of mirtazapine for digestive symptoms in palliative care \u2013 retrospective study of 50 cases]. Gan To Kagaku Ryoho 2014; 41: 329\u2013333.","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2021.05.017"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0425-1"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-020-00903-8"},{"key":"e_1_3_4_50_2","first-page":"451","article-title":"Comparison of mirtazapine and olanzapine on nausea and vomiting following anthracycline-cyclophosphamide chemotherapy regimen in patients with breast cancer","volume":"19","author":"Maleki A","year":"2020","unstructured":"Maleki A, Ghadiyani M, Salamzadeh J, et al. Comparison of mirtazapine and olanzapine on nausea and vomiting following anthracycline-cyclophosphamide chemotherapy regimen in patients with breast cancer. Iran J Pharm Res 2020; 19: 451\u2013464.","journal-title":"Iran J Pharm Res"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16277"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102512"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen241"},{"key":"e_1_3_4_54_2","first-page":"5061803","article-title":"A randomized controlled trial for prevention of postspinal anesthesia shivering in gynecological surgeries: mirtazapine vs. dexamethasone","volume":"2022","author":"Esmat IM","year":"2022","unstructured":"Esmat IM, Elsayed AM, El-Hariri HM, et al. A randomized controlled trial for prevention of postspinal anesthesia shivering in gynecological surgeries: mirtazapine vs. dexamethasone. Anesthesiol Res Pract 2022; 2022: 5061803.","journal-title":"Anesthesiol Res Pract"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S125743"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e318209cef2"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.07.002"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.8.1341-a"},{"key":"e_1_3_4_59_2","first-page":"468","article-title":"Comparison of the potency of nortriptyline and mirtazapine on gastrointestinal symptoms, the level of anxiety and depression in patients with functional dyspepsia","volume":"16","author":"Jamshidfar N","year":"2023","unstructured":"Jamshidfar N, Hamdieh M, Eslami P, et al. Comparison of the potency of nortriptyline and mirtazapine on gastrointestinal symptoms, the level of anxiety and depression in patients with functional dyspepsia. Gastroenterol Hepatol Bed Bench 2023; 16: 468\u2013477.","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.025"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2014-000790"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.025"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(02)00645-0"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02473-3"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199815010-00006"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012067703764"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038060-00001"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.podrm.2018.01.002"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199512004-00004"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v58n1108"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90149-9"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n1013"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00882-9"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00266.2002"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05229-7"},{"key":"e_1_3_4_76_2","volume-title":"Aromatherapy and essential oils: a map of the evidence","author":"Freeman M","year":"2019","unstructured":"Freeman M, Ayers C, Peterson C, et al. Aromatherapy and essential oils: a map of the evidence. VA Evidence-based Synthesis Program Reports. Washington (DC): Department of Veterans Affairs (US), 2019."},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.4103\/sja.sja_151_23"},{"key":"e_1_3_4_78_2","first-page":"580","article-title":"Inhaled isopropyl alcohol for nausea and vomiting in the emergency department","volume":"64","author":"Lindblad AJ","year":"2018","unstructured":"Lindblad AJ, Ting R, Harris K. Inhaled isopropyl alcohol for nausea and vomiting in the emergency department. Can Fam Physician 2018; 64: 580.","journal-title":"Can Fam Physician"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006527-200410000-00005"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200203000-00009"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2022.0332"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2015.09.031"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12245-021-00334-z"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.12.052"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2022-212871"},{"key":"e_1_3_4_86_2","first-page":"293","article-title":"Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV","volume":"77","author":"Pellegrini J","year":"2009","unstructured":"Pellegrini J, DeLoge J, Bennett J, et al. Comparison of inhalation of isopropyl alcohol vs promethazine in the treatment of postoperative nausea and vomiting (PONV) in patients identified as at high risk for developing PONV. AANA J 2009; 77: 293\u2013299.","journal-title":"AANA J"},{"key":"e_1_3_4_87_2","first-page":"127","article-title":"Comparison of inhaled isopropyl alcohol and intravenous ondansetron for treatment of postoperative nausea","volume":"71","author":"Winston AW","year":"2003","unstructured":"Winston AW, Rinehart RS, Riley GP, et al. Comparison of inhaled isopropyl alcohol and intravenous ondansetron for treatment of postoperative nausea. AANA J 2003; 71: 127\u2013132.","journal-title":"AANA J"},{"key":"e_1_3_4_88_2","article-title":"Prophylactic isopropyl alcohol inhalation and intravenous ondansetron versus ondansetron alone in the prevention of postoperative nausea and vomiting in high-risk patients","volume":"79","author":"Radford KD","year":"2011","unstructured":"Radford KD, Fuller TN, Bushey B, et al. Prophylactic isopropyl alcohol inhalation and intravenous ondansetron versus ondansetron alone in the prevention of postoperative nausea and vomiting in high-risk patients. AANA J 2011; 79(4 Suppl): S69\u2013S74.","journal-title":"AANA J"},{"key":"e_1_3_4_89_2","first-page":"21","article-title":"A comparative analysis of isopropyl alcohol and ondansetron in the treatment of postoperative nausea and vomiting from the hospital setting to the home","volume":"75","author":"Cotton JW","year":"2007","unstructured":"Cotton JW, Rowell LR, Hood RR, et al. A comparative analysis of isopropyl alcohol and ondansetron in the treatment of postoperative nausea and vomiting from the hospital setting to the home. AANA J 2007; 75: 21\u201326.","journal-title":"AANA J"},{"key":"e_1_3_4_90_2","first-page":"417","article-title":"The effectiveness of inhalation isopropyl alcohol vs. granisetron for the prevention of postoperative nausea and vomiting","volume":"75","author":"Teran L","year":"2007","unstructured":"Teran L, Hawkins JK. The effectiveness of inhalation isopropyl alcohol vs. granisetron for the prevention of postoperative nausea and vomiting. AANA J 2007; 75: 417\u2013422.","journal-title":"AANA J"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2003.11.001"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-018-1094-3"},{"key":"e_1_3_4_93_2","article-title":"Aromatherapy for treatment of postoperative nausea and vomiting","volume":"3","author":"Hines S","year":"2018","unstructured":"Hines S, Steels E, Chang A, et al. Aromatherapy for treatment of postoperative nausea and vomiting. Cochrane Database Syst Rev 2018; 3: CD007598.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-023-03560-x"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31824a0b1c"}],"container-title":["Palliative Care and Social Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26323524241257701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/26323524241257701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26323524241257701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:02:34Z","timestamp":1777597354000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/26323524241257701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":94,"alternative-id":["10.1177\/26323524241257701"],"URL":"https:\/\/doi.org\/10.1177\/26323524241257701","relation":{},"ISSN":["2632-3524","2632-3524"],"issn-type":[{"value":"2632-3524","type":"print"},{"value":"2632-3524","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]},"article-number":"26323524241257701"}}