{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:05:38Z","timestamp":1792188338779,"version":"4.4.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliat&amp;#65533;Care"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Potentially inappropriate medications (PIMs) pose a significant burden on patients with advanced cancer approaching the end of life. However, trends in the prescription of PIMs and the factors associated with deprescribing PIMs in these patients remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe trends in the prescription of PIMs and explore the factors associated with the deprescribing of PIMs in patients with advanced cancer in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study using medical claims data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed patients aged &gt;65\u2009years who were diagnosed with cancer 6\u2009months before death and died between December 2017 and August 2023 in the city of Mito, Ibaraki prefecture, Japan. Sociodemographic, clinical, and prescription data were collected at 6\u2009months (M6), 3\u2009months (M3), and 1\u2009month (M1) before death. PIMs were assessed according to the OncPal Deprescribing Guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of 1269 patients was 80.6\u2009years, and 62.2% were male. PIMs were prescribed to 77.0% at M6, 76.4% at M3, and 70.0% at M1 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001, M6 to M1). The factors associated with deprescribing at least one PIM from M6 to M1 included female sex, number of medications at M6, number of comorbidities, admission to a palliative care unit, and admission to a general ward.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients with advanced cancer, PIM use decreased as they approached death. Deprescribing PIMs was more common in females, patients with polypharmacy and comorbidities, and patients admitted to hospitals, especially palliative care units.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26323524251403020","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T06:04:10Z","timestamp":1765865050000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Trends in prescriptions and factors associated with discontinuation of potentially inappropriate medications in elderly patients with advanced cancer at the end of life: A retrospective cohort study"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7433-1625","authenticated-orcid":false,"given":"Shoichi","family":"Masumoto","sequence":"first","affiliation":[{"name":"Department of Family Medicine, General Practice and Community Health, Institute of Medicine, University of Tsukuba, Ibaraki, Japan"},{"name":"Department of General Medicine, Tsukuba Central Hospital, Ushiku, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-4333","authenticated-orcid":false,"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Medical Education, Institute of Medicine, University of Tsukuba, Ibaraki, Japan"},{"name":"Department of Health Services Research, Institute of Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-6684","authenticated-orcid":false,"given":"Mikiya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, Institute of Medicine, University of Tsukuba, Ibaraki, Japan"},{"name":"Occupational Safety and Health Department, Human Resources Group, Sumitomo Heavy Industries, Ltd., Shinagawa-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-0097","authenticated-orcid":false,"given":"Kenji","family":"Momo","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmaceutics, School of Pharmacy, Showa Medical University, Shinagawa-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0304-9881","authenticated-orcid":false,"given":"Jun","family":"Hamano","sequence":"additional","affiliation":[{"name":"Division of Clinical Medicine, Institute of Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-5446","authenticated-orcid":false,"given":"Chihiro","family":"Nishiura","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Medical Education, Institute of Medicine, University of Tsukuba, Ibaraki, Japan"},{"name":"Labita LLC, Ota-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-4990","authenticated-orcid":false,"given":"Kenji","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Occupational Health Data Science Center, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-776X","authenticated-orcid":false,"given":"Tetsuhiro","family":"Maeno","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Medical Education, Institute of Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0621-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00080-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2015-000941"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01124.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32044"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcsop.2021.100050"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16091152"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2507-4"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.0324"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/02692163231209024"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06605-y"},{"key":"e_1_3_3_13_2","first-page":"71","article-title":"The development and evaluation of an oncological palliative care deprescribing guideline: the \u201cOncPal deprescribing guideline.\u201d","volume":"23","author":"Lindsay J","year":"2015","unstructured":"Lindsay J, Dooley M, Martin J, et al. The development and evaluation of an oncological palliative care deprescribing guideline: the \u201cOncPal deprescribing guideline.\u201d Support Care Cancer 2015; 23: 71\u201378.","journal-title":"Support Care Cancer"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2023.0520"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.31662\/jmaj.2018-0016"},{"key":"e_1_3_3_16_2","unstructured":"Mito City. Data health plan (second phase) of Mito City National Health Insurance https:\/\/www.city.mito.lg.jp\/uploaded\/attachment\/47339.pdf (2024 accessed 11 April 2025)."},{"key":"e_1_3_3_17_2","unstructured":"Ministry of Health Labour and Welfare. 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BMJ Support Palliat Care 2024; 13: e1156\u2013e1165.","journal-title":"BMJ Support Palliat Care"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.795043"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13874"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15079"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-019-00797-4"},{"key":"e_1_3_3_31_2","first-page":"761","article-title":"The impact of palliative care consults on medicines optimisation for patients with cancer referred to hospice care at the end of life: a retrospective cohort study","volume":"33","author":"Alwidyan T","year":"2025","unstructured":"Alwidyan T, Shamieh O, Alrjoub W, et al. The impact of palliative care consults on medicines optimisation for patients with cancer referred to hospice care at the end of life: a retrospective cohort study. 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