{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:13:01Z","timestamp":1777882381615,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Rare Disease"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Here, we describe two congenitally deaf male siblings with the same compound heterozygotic, likely pathogenic mutations in the FGF3 gene, associated with the labyrinthine aplasia, microtia and microdontia (LAMM) syndrome. Both children had bilateral cochleovestibular aplasia, precluding cochlear implantation. The elder brother received an auditory brainstem implant (ABI) with very limited auditory responses. During the ABI-surgery of the younger subject, it was discovered that excellent auditory responses could be obtained when the electrode array was placed considerably more caudally and more medially than standard. It was observed that the foramen of Luschka, the entrance to the lateral recess of the fourth ventricle was located more caudally. In view of this observation the good auditory development of the latter child, it was decided to give the older child a contralateral ABI. Again, it turned out that the anatomy of the brainstem was abnormal with a more caudal location of the foramen of Luschka and the cochlear nucleus, and this child is showing good progress with his auditory development. It is concluded that one should be aware of the anatomical differences at the level of the brainstem when placing an ABI in children with this genetic disorder (and most likely also in the LAMM syndrome). This also underpins the need of a multidisciplinary approach with closely collaborating team members and good family guidance when diagnosing and treating children with rare deafness.<\/jats:p>","DOI":"10.1177\/26330040241290834","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T14:27:19Z","timestamp":1729175239000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroanatomical anomalies due to a defect in the FGF3 gene, associated with the Labyrinthine Aplasia, Microtia and Microdontia syndrome: insights from the placement of auditory brainstem implants in two siblings"],"prefix":"10.1177","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-3314","authenticated-orcid":false,"given":"Johan H. M.","family":"Frijns","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology & HNS, Leiden University Medical Centre, P.O. Box 9600, Leiden, 2300 RC, The Netherlands"},{"name":"Bioelectronics Group, Faculty of EEMCS, Delft University of Technology, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1425-8096","authenticated-orcid":false,"given":"(Roos) M. G. S.","family":"Geerders","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & HNS, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Scholing","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & HNS, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-2583","authenticated-orcid":false,"given":"Berit M.","family":"Verbist","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radboud W.","family":"Koot","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn J. A.","family":"Malessy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter-Paul B. M.","family":"Boermans","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & HNS, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4302-817X","authenticated-orcid":false,"given":"Jeroen J.","family":"Briaire","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology & HNS, Leiden University Medical Centre, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"bibr1-26330040241290834","unstructured":"MedlinePlus. FGF3 gene, https:\/\/medlineplus.gov\/genetics\/gene\/fgf3 (2012, accessed 13 March 2024)."},{"key":"bibr2-26330040241290834","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12072"},{"key":"bibr3-26330040241290834","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.2168"},{"key":"bibr4-26330040241290834","doi-asserted-by":"publisher","DOI":"10.3390\/genes10070529"},{"key":"bibr5-26330040241290834","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0000000000000254"},{"key":"bibr6-26330040241290834","first-page":"8563961","volume":"2016","author":"Pathivada L","year":"2016","journal-title":"Case Rep Dent"},{"key":"bibr7-26330040241290834","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20689"},{"key":"bibr8-26330040241290834","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.111995.3"},{"key":"bibr9-26330040241290834","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001050"},{"key":"bibr10-26330040241290834","first-page":"135","volume":"119","author":"Behr R","year":"2022","journal-title":"Dtsch Arztebl Int"},{"key":"bibr11-26330040241290834","first-page":"3","volume-title":"Auditory brainstem implants","author":"Rosahl SK","year":"2021"},{"key":"bibr12-26330040241290834","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181b07d41"},{"key":"bibr13-26330040241290834","doi-asserted-by":"publisher","DOI":"10.5152\/iao.2014.135"},{"key":"bibr14-26330040241290834","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002306"},{"key":"bibr15-26330040241290834","first-page":"112","volume":"83","author":"Schaaij-Gulpen PMB","year":"2011","journal-title":"Logopedie en Foniatrie"},{"key":"bibr16-26330040241290834","doi-asserted-by":"publisher","DOI":"10.1177\/0003489400109S1217"},{"key":"bibr17-26330040241290834","first-page":"312","volume":"166","author":"Archbold S","year":"1995","journal-title":"Ann Otol Rhinol Laryngol Suppl"}],"container-title":["Therapeutic Advances in Rare Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26330040241290834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/26330040241290834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26330040241290834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:10:34Z","timestamp":1777597834000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/26330040241290834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":17,"alternative-id":["10.1177\/26330040241290834"],"URL":"https:\/\/doi.org\/10.1177\/26330040241290834","relation":{},"ISSN":["2633-0040","2633-0040"],"issn-type":[{"value":"2633-0040","type":"print"},{"value":"2633-0040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"26330040241290834"}}