{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:13:08Z","timestamp":1777882388298,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Rare Disease"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>Beh\u00e7et\u2019s disease is a kind of variable vessel vasculitis (VVV) and inflammatory systematic disease affecting various organs of the body. The cause of the disease is idiopathic but is most commonly genetic in origin. A positive skin prick test (dermatographia), genital sores, eye irritation, skin sores, and at least three episodes of mouth sores in a year confirm the diagnosis. Treatment may include immunosuppressive agents, immune modulators, and biological markers such as corticosteroids, immunosuppressants, and antibodies. We report a case of a 23-year-old male patient, presented in an outpatient clinic in a tertiary care eye hospital located in Pakistan. The patient reported sudden loss of vision in one eye and graduate loss of vision in the other eye. Ocular and systemic investigations were performed to correlate with clinical findings to reach a diagnosis. The patient was managed symptomatically and was put on corticosteroids. Our hospital is a research and postgraduate educational institution that deals with complex eye diseases. The range of investigations and clinical exams helped clinical decision-makers in evaluating the patient\u2019s diagnosis.<\/jats:p>","DOI":"10.1177\/26330040251314126","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T06:37:44Z","timestamp":1737182264000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Behcet\u2019s disease in a tertiary eye hospital in Pakistan"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1306-0589","authenticated-orcid":false,"given":"Tabish Ali","family":"Shalwani","sequence":"first","affiliation":[{"name":"Liaquat University of Medical and Health Sciences, Jamshoro 74800, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alishan","family":"Khowaja","sequence":"additional","affiliation":[{"name":"Liaquat College of Medicine and Dentistry, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narmeen","family":"Punjwani","sequence":"additional","affiliation":[{"name":"Jinnah Medical and Dental College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-5305-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.625710"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-021-01011-z"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0973369820070205"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.17-1-71"},{"key":"e_1_3_4_7_2","unstructured":"CARE checklist. https:\/\/www.equator-network.org\/reporting-guidelines\/care\/ (accessed 11 December 2024)."},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.02.011"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215174"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.03.022"},{"key":"e_1_3_4_11_2","first-page":"2016","article-title":"Eclectic ocular comorbidities and systemic diseases with eye involvement: a review","author":"Pinazo-Dur\u00e1n MD","year":"2016","unstructured":"Pinazo-Dur\u00e1n MD, Zan\u00f3n-Moreno V, Garc\u00eda-Medina JJ, et al. Eclectic ocular comorbidities and systemic diseases with eye involvement: a review. BioMed Res Int 2016; 2016.","journal-title":"BioMed Res Int"},{"issue":"4","key":"e_1_3_4_12_2","first-page":"612","article-title":"Spectrum of ocular manifestations of rheumatic autoimmune diseases: a tertiary care experience in Pakistan","volume":"33","author":"Uddin Z","year":"2021","unstructured":"Uddin Z, Khan A, Haroon M, et al. Spectrum of ocular manifestations of rheumatic autoimmune diseases: a tertiary care experience in Pakistan. J Ayub Med Coll Abbottabad 2021; 33(4): 612.","journal-title":"J Ayub Med Coll Abbottabad"},{"issue":"11","key":"e_1_3_4_13_2","first-page":"1242","article-title":"Regression of severe Behcet\u2019s eye disease with infliximab therapy; first two cases treated in Pakistan","volume":"62","author":"Ishaq S","year":"2012","unstructured":"Ishaq S, Saeed A, Jawad M. Regression of severe Behcet\u2019s eye disease with infliximab therapy; first two cases treated in Pakistan. J Pak Med Assoc 2012; 62(11): 1242\u20131244.","journal-title":"J Pak Med Assoc"},{"issue":"11","key":"e_1_3_4_14_2","first-page":"730","article-title":"Multifocal venous thrombosis in Behcet\u2019s disease","volume":"22","author":"Jafri L","year":"2012","unstructured":"Jafri L, Nasir N, Almas A. Multifocal venous thrombosis in Behcet\u2019s disease. J Coll Physicians Surg Pak 2012; 22(11): 730\u2013732.","journal-title":"J Coll Physicians Surg Pak"},{"issue":"5","key":"e_1_3_4_15_2","first-page":"1005","article-title":"Behcet\u2019s disease: Pakistani experience","volume":"36","author":"Khan A","year":"2020","unstructured":"Khan A, Haroon M, Bashir F, et al. Behcet\u2019s disease: Pakistani experience. Pakistan J Med Sci 2020; 36(5): 1005.","journal-title":"Pakistan J Med Sci"}],"container-title":["Therapeutic Advances in Rare Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26330040251314126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/26330040251314126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26330040251314126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:10:41Z","timestamp":1777597841000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/26330040251314126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,18]]},"references-count":14,"alternative-id":["10.1177\/26330040251314126"],"URL":"https:\/\/doi.org\/10.1177\/26330040251314126","relation":{},"ISSN":["2633-0040","2633-0040"],"issn-type":[{"value":"2633-0040","type":"print"},{"value":"2633-0040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,18]]},"article-number":"26330040251314126"}}