{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:17:28Z","timestamp":1777605448191,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Exp Neurosci"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Late-onset Alzheimer\u2019s disease (LOAD) is the most common age-related dementia, and its etiology remains unclear. Recent studies have linked abnormal neuronal aging to LOAD. Neurons are non-proliferative, and thus, majority of aged neurons must be rejuvenated through repairing or eliminating damaged molecules to regain their healthy status and functionalities. We discovered a surge of oxidative stress in neurons at middle age in mice. A rapid upregulation of neuronal rejuvenation is vital, while astrocyte-expressed interleukin33 (IL33), an IL1-like cytokine, is critical for this process. Thus, IL33-deficiency cripples the neuronal rejuvenation mechanisms, such as repairing DNA double strand breaks, eliminating damaged molecules by autophagy or by glymphatic drainage. IL33-deficient mice develop tau deposition and age-related dementia following a path similar to LOAD. We hypothesize that any interferences on IL33-initiated rejuvenation process for aged neurons after middle life is a potential risk for LOAD development.<\/jats:p>","DOI":"10.1177\/26331055211030251","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T07:27:26Z","timestamp":1626679646000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of Interleukin33 in Rejuvenation of Aged Neurons and Age-Related Dementias"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-2425","authenticated-orcid":false,"given":"Yahuan","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Diagnostic Science, University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"bibr1-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz4564"},{"key":"bibr2-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00341-9"},{"key":"bibr3-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"bibr4-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12969"},{"key":"bibr5-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9897"},{"key":"bibr6-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3232"},{"key":"bibr7-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.119"},{"key":"bibr8-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2660"},{"key":"bibr9-26331055211030251","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402503"},{"key":"bibr10-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.006"},{"key":"bibr11-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.10"},{"key":"bibr12-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604032113"},{"key":"bibr13-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.176"},{"key":"bibr14-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0626-7"},{"key":"bibr15-26331055211030251","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00992-0"}],"container-title":["Neuroscience Insights"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26331055211030251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/26331055211030251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26331055211030251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:03:37Z","timestamp":1777410217000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/26331055211030251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":15,"alternative-id":["10.1177\/26331055211030251"],"URL":"https:\/\/doi.org\/10.1177\/26331055211030251","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/26331055211030251\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2633-1055","2633-1055"],"issn-type":[{"value":"2633-1055","type":"print"},{"value":"2633-1055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"26331055211030251"}}