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However, recent evidence suggests aberrant VEGF-A signaling in Alzheimer\u2019s disease may undermine its physiological angiogenic function. Instead of improving cerebral blood flow, VEGF-A contributes to brain capillary stalls and blood flow reductions, likely accelerating cognitive decline. In this commentary, we explore the evidence for pathological VEGF signaling in Alzheimer\u2019s disease, and discuss its implications for disease therapy.<\/jats:p>","DOI":"10.1177\/26331055221109254","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T01:32:46Z","timestamp":1656984766000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":33,"title":["VEGF Paradoxically Reduces Cerebral Blood Flow in Alzheimer\u2019s Disease Mice"],"prefix":"10.1177","volume":"17","author":[{"given":"Muhammad","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-6590","authenticated-orcid":false,"given":"Oliver","family":"Bracko","sequence":"additional","affiliation":[{"name":"Department of Biology, University 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