{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:17:41Z","timestamp":1777605461631,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["81671365"],"award-info":[{"award-number":["81671365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Exp Neurosci"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Obsessive-compulsive disorder (OCD) is a chronic and debilitating mental disorder that affects patients throughout their lives, leading to a diminished quality of life for patients and families, reduced productivity, and higher health care costs. It is of clinical and theoretical importance to investigate a more efficacious therapeutic approach for OCD and the neurophysiological mechanism underlying the efficacy of treatment, potentially associated with the etiology of OCD. Recently, a novel psychotherapy designated cognitive-coping therapy (CCT) has been reported to have a large effect size in OCD treatment. CCT hypothesizes that fear of negative events plays a crucial role in OCD. The study entitled \u201cDecreased left amygdala functional connectivity by cognitive-coping therapy in obsessive-compulsive disorder\u201d attempted to investigate the potential neurophysiological mechanism underlying the efficacy of CCT for OCD. The study provides crystal evidence showing that 4-week pharmacotherapy plus CCT decreases the left amygdala seed-based functional connectivity (LA-FC) with the right anterior cingulate gyrus and the left paracentral lobule\/the left superior parietal\/left inferior parietal, and 4-week CCT decreases the LA-FC with the left middle occipital gyrus\/the left superior parietal. The alteration of the LA-FC with the right anterior cingulate gyrus positively correlates to the reduction of the Yale-Brown obsessive-compulsive scale (Y-BOCS) score. Therefore, it provides new insights into understanding the neurophysiology and neuropsychology behind the onset and treatment of OCD.<\/jats:p>","DOI":"10.1177\/26331055221114823","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T06:32:16Z","timestamp":1658557936000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Left Amygdala Functional Connectivity Decreased after Fear of Negative Events was Disregarded in Obsessive-Compulsive Disorder"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0913-0536","authenticated-orcid":false,"given":"Xian-Zhang","family":"Hu","sequence":"first","affiliation":[{"name":"Xinxiang Medical University, Xinxiang City, Henan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"bibr1-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.94"},{"key":"bibr2-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70177-5"},{"key":"bibr3-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.2.121"},{"key":"bibr4-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1097\/01.pra.0000300122.76322.ad"},{"key":"bibr5-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2004.11.012"},{"key":"bibr6-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1111\/acps.13276"},{"key":"bibr7-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13354"},{"key":"bibr8-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.08.010"},{"key":"bibr9-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.08.002"},{"key":"bibr10-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2019.101878"},{"key":"bibr11-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.10.015"},{"key":"bibr12-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2020.103707"},{"key":"bibr13-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002134"},{"key":"bibr14-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1992.01820090009002"},{"key":"bibr15-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.210084"},{"key":"bibr16-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01131-z"},{"key":"bibr17-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.914"},{"key":"bibr18-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.249"},{"key":"bibr19-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2018.01.009"},{"key":"bibr20-26331055221114823","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.04.022"}],"container-title":["Neuroscience Insights"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26331055221114823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/26331055221114823","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26331055221114823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:03:39Z","timestamp":1777410219000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/26331055221114823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":20,"alternative-id":["10.1177\/26331055221114823"],"URL":"https:\/\/doi.org\/10.1177\/26331055221114823","relation":{},"ISSN":["2633-1055","2633-1055"],"issn-type":[{"value":"2633-1055","type":"print"},{"value":"2633-1055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"26331055221114823"}}