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In Caenorhabditis elegans, the cadherin CDH-4 is required for ventral nerve cord axonal navigation, and dorsal nerve cord fasciculation. How CDH-4 mediates axon navigation and fasciculation is currently unknown. To identify genes acting together with cdh-4, we isolated mutants suppressing the axon guidance defects of cdh-4 mutants. These suppressors showed partial suppression of axonal defects in the dorsal and ventral nerve cords seen in cdh-4 mutants. We identified one suppressor gene, prp-6, which encodes a component of the spliceosome. Complete loss-of-function alleles of prp-6 are lethal, suggesting that the mutation isolated in our suppressor screen is a partial loss-of-function allele. A previous study found that RNAi-induced suppression of prp-6 leads to changes in the expression of several 100 genes including the cadherin cdh-5. We found that overexpression of cdh-5 mimics the suppression seen in prp-6 mutants, suggesting that CDH-5 can partially compensate for the loss of CDH-4.<\/jats:p>","DOI":"10.1177\/26331055221123346","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T05:24:53Z","timestamp":1662441893000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mutations in the Spliceosome Component\n                    <i>prp-6<\/i>\n                    and Overexpression of\n                    <i>cdh-5<\/i>\n                    Suppress Axon Guidance Defects of\n                    <i>cdh-4<\/i>\n                    Mutants in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1177","volume":"17","author":[{"given":"Zina","family":"Aburegeba","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Simon Fraser University, Burnaby, BC, 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