{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:07:34Z","timestamp":1784934454806,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Exp Neurosci"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The most prevalent type of radiologist error is failing to detect abnormalities on images, the so-called \u201cperceptual error.\u201d The prevalence of this type of false-negative (FN) error remains essentially unchanged since it was first described in 1949. Reducing this error rate would be highly beneficial for patients who often depend on radiological observations for a timely diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify a potential neurocognitive mechanism contributing to radiologists\u2019 perceptual errors, in order to inform intervention strategies to reduce such errors in practice. These experiments evaluated the relationship between brain network activation states and radiologists\u2019 perceptual errors on two distinct visual tasks utilizing functional MRI (fMRI) and functional Near Infrared Spectroscopy (fNIRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A prospective, pilot study was carried out on a small number of radiologist participants utilizing two distinct types of visual tasks while monitoring activity in two targeted brain networks, the default mode network (DMN) and the \u201cexecutive\u201d frontoparietal network (FPN), to test the hypothesis that simultaneous co-activation of these networks produces an error-prone neurocognitive state (EPS). A third experiment using fNIRS alone was an observational study of subjects\u2019 neurocognitive states during their usual practice to determine the baseline prevalence of the EPS in the clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An approximately threefold increased risk of FN perceptual errors (misses) on the visual tasks was observed in the presence of simultaneous co-activation of elements of the Default Mode Network (DMN) and Frontoparietal Network (FPN), which supports the \u201cerror-prone state\u201d (EPS) hypothesis. EPS prevalence declined with participant age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that dynamic interactions between the Default Mode Network (DMN) and Frontoparietal Network (FPN) create a unique error-prone state (EPS), associated with an approximately threefold increased risk of perceptual error in radiologists. These results suggest potential intervention strategies for perceptual error, the largest class of radiologist errors in practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26331055261470384","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:40:21Z","timestamp":1784630421000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurocognitive Mechanism of Perceptual Errors in Radiologists: Results of Pilot Studies"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0470-9706","authenticated-orcid":false,"given":"Michael A.","family":"Bruno","sequence":"first","affiliation":[{"name":"Penn State Health"},{"name":"Penn State College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Krupinski","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C.","family":"Bunce","sequence":"additional","affiliation":[{"name":"Penn State Health"},{"name":"Penn State College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-9886","authenticated-orcid":false,"given":"Grayson L.","family":"Baird","sequence":"additional","affiliation":[{"name":"Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Mills","sequence":"additional","affiliation":[{"name":"University of Minnesota Twin Cities"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna R.","family":"Karunanayaka","sequence":"additional","affiliation":[{"name":"Penn State Health"},{"name":"Penn State College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Egeth","sequence":"additional","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Chang","sequence":"additional","affiliation":[{"name":"Mallincrodt Institute of Radiology, Washington University, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Cottrill","sequence":"additional","affiliation":[{"name":"Penn State Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Jump","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnankutty","family":"Sathian","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Mosher","sequence":"additional","affiliation":[{"name":"Penn State Health"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2018180021"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2015150023"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.16.16963"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11493"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/52.3.309"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1270"},{"issue":"1","key":"e_1_3_6_8_2","first-page":"79","article-title":"Radiologic errors","volume":"1","author":"Berlin L","year":"2014","unstructured":"Berlin L. Radiologic errors. past, present and future\u201d Diagnosis (Berl). 2014;1(1):79-84.","journal-title":"past, present and future\u201d Diagnosis (Berl)"},{"key":"e_1_3_6_9_2","first-page":"74","article-title":"Improving patient care through medical image perception research: Policy Insights","volume":"2","author":"Krupinski EA","year":"2015","unstructured":"Krupinski EA. Improving patient care through medical image perception research: Policy Insights. Behav Brain Sciences. 2015;2:74-80.","journal-title":"Behav Brain Sciences"},{"issue":"7","key":"e_1_3_6_10_2","first-page":"319","article-title":"Meta-awareness, perceptual decoupling and the wandering mind","volume":"15","author":"Schooler JW","year":"2011","unstructured":"Schooler JW, Smallwood J, Christoff K, Handy TC, Reichle ED, Sayette MA. Meta-awareness, perceptual decoupling and the wandering mind. Trends in cognitive Sciences. 2011;15(7):319-326.","journal-title":"Trends in cognitive Sciences"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.03.072"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900234106"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90355.2008"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00281"},{"key":"e_1_3_6_17_2","first-page":"249","volume-title":"The Oxford handbook of spontaneous thought: Mind-wandering, creativity, and dreaming","author":"Kam JW","year":"2018","unstructured":"Kam JW, Handy TC. Electrophysiological evidence for attentional decoupling during mind-wandering. In: The Oxford handbook of spontaneous thought: Mind-wandering, creativity, and dreaming; 2018;249-258."},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1727"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2007.01948.x"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131295"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0956797610378686"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2062-14.2014"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00656"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-197805000-00001"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2016.03.004"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1003\/hbm.23440"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708965105"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000260"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actpsy.2013.10.016"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2010.03.004"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.3791\/65088"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.07.001"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.005"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep38866"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2024.08.030"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18613"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715766115"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/07370024.2020.1716762"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117412"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-025-02847-a"}],"container-title":["Neuroscience Insights"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26331055261470384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/26331055261470384","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26331055261470384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:46:37Z","timestamp":1784933197000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/26331055261470384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":39,"alternative-id":["10.1177\/26331055261470384"],"URL":"https:\/\/doi.org\/10.1177\/26331055261470384","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/26331055261470384\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/26331055261470384\/v2\/review1","asserted-by":"object"}]},"ISSN":["2633-1055","2633-1055"],"issn-type":[{"value":"2633-1055","type":"print"},{"value":"2633-1055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"26331055261470384"}}