{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:13:47Z","timestamp":1777882427481,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Med\ufffdInsights\ufffdReprod\ufffdHealth"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Preeclampsia is a leading cause of maternal morbidity and mortality. Various predictive methods exist, but none are without flaws. Risk factors vary in different women and at different gestational ages; hence, investigating non-modifiable factors, such as ABO and Rhesus blood groups, may aid prediction and early detection of preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the association between maternal ABO blood groups and preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This was a prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study included singleton, normotensive, Rhesus-positive primigravidae with different ABO blood groups at &lt;20\u2009weeks of gestation. The primary outcome was the incidence of preeclampsia in mothers with Rhesus (D)-positive ABO blood groups (O, A, B and AB), while the secondary outcomes were the overall preeclampsia incidence and the odds ratio for preeclampsia between blood group O and non-O (A, B and AB) participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 264 participants were enrolled, with 244 followed up until delivery. Eighteen participants developed preeclampsia with an incidence of 7.4% (95% confidence interval: 3.9\u201310.7). Most participants had blood group O (57.0%), followed by A (29.5%), B (12.7%) and AB (0.8%). The mean gestational age at preeclampsia onset was 37.8\u2009\u00b1\u20092\u2009weeks. Blood group AB had the highest incidence of preeclampsia (50%), followed by B (16.1%), O (5.8%) and A (5.6%). Among 105 participants with non-O blood groups, 10 developed preeclampsia (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.265). The adjusted odds ratio for the non-O blood group who developed preeclampsia was 1.65.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Maternal ABO blood group was not significantly associated with preeclampsia incidence. However, blood group AB exhibited the highest preeclampsia incidence compared with the other blood groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26334941251338621","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:59:49Z","timestamp":1746759589000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between maternal ABO blood group and preeclampsia: a prospective cohort study"],"prefix":"10.1177","volume":"19","author":[{"given":"Zebulon C.","family":"Okechukwu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George U.","family":"Eleje","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph I.","family":"Adinma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald O.","family":"Udigwe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Innocent I.","family":"Mbachu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chukwuemeka O.","family":"Ezeama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nkiru N.","family":"Ezeama","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chukwudi A.","family":"Ogabido","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chukwunwendu F.","family":"Okeke","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"},{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chidinma C.","family":"Okafor","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Leicestershire Partnership NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella C.","family":"Okechukwu","sequence":"additional","affiliation":[{"name":"Department of Medical Social Services, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinedu L.","family":"Olisa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4458-8216","authenticated-orcid":false,"given":"Chigozie G.","family":"Okafor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital (NAUTH), PMB 5025, Nnewi, Anambra State 435101, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_3_4_2_2","article-title":"Comparison of urine protein-creatinine ratio and urine dipstick test for significant proteinuria in preeclamptic women","volume":"18","author":"Olisa CL","year":"2024","unstructured":"Olisa CL, Nwosu BO, Eleje GU, et al. 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