{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:40:12Z","timestamp":1777516812241,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"British Medical Association Foundation","award":["Bhautesh Jani"],"award-info":[{"award-number":["Bhautesh Jani"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Multimorbidity and Comorbidity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Aims<\/jats:title>\n                    <jats:p>Upper gastrointestinal cancers (oesophageal\/stomach) have high mortality rates and are often diagnosed after the disease has progressed, making it important to identify populations at greater risk of upper gastrointestinal (UGI) cancer to promote earlier diagnosis. This study aims to determine if there is an association between a broad range of long-term conditions (LTCs) and incidence of UGI cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A prospective-based cohort of 487,798 UK Biobank participants (age 37\u201373\u00a0years) after excluding previous UGI cancer. Least Absolute Shrinkage and Selection Operator (LASSO) regression used to identify candidate LTCs as predictors for UGI cancer. Strength of association was studied using Cox\u2019s regression adjusting for demographics and lifestyle factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After median follow-up period of 86 months, 598 participants developed oesophageal cancer; 397 developed stomach cancer. In fully adjusted models, participants with alcohol addiction (Hazard Ratio-HR 4.11, 95% Confidence Interval-CI 2.01\u20138.43), Barrett\u2019s oesophagus (HR 5.68, 95% CI 3.36\u20139.58), bronchiectasis (HR 2.72, 95% CI 1.01\u20137.31), diabetes (HR 1.38, 95% CI 1.06\u20131.81), hiatus hernia (HR 1.69, 95% CI 1.16\u20132.45), Parkinson\u2019s disease (HR 3.86, 95% CI 1.60\u20139.37) and psoriasis\/eczema (HR 1.53, 95% 1.08\u20132.17) were observed to have a higher risk of oesophageal cancer. Stomach cancer incidence was higher among participants with anorexia\/bulimia (HR 8.86, 95% CI 1.20\u201365.14), Barrett\u2019s oesophagus (HR 3.37, 95% 1.39\u20138.14), chronic fatigue syndrome (HR 3.36, 95% CI 1.25\u20139.03), glaucoma (HR 2.06, 95% CI 1.16\u20133.67), multiple sclerosis (HR 4.60, 95% CI 1.71\u201312.34), oesophageal stricture (HR 1.04, 95% CI 1.46\u201374.46) and pernicious anaemia (HR 6.93, 95% CI 3.42\u201314.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Previously unrecognised LTCs may have a role in symptom appraisal and risk assessment of UGI cancer in primary care. Further research should explore mechanisms underpinning these findings and determine whether they are replicable in other populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26335565211056136","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T02:19:02Z","timestamp":1637201942000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations between long-term conditions and upper gastrointestinal cancer incidence: A prospective population-based cohort of UK Biobank participants"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-6159","authenticated-orcid":false,"given":"Jennifer","family":"Marley","sequence":"first","affiliation":[{"name":"General Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-0130","authenticated-orcid":false,"given":"Barbara I","family":"Nicholl","sequence":"additional","affiliation":[{"name":"General Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Macdonald","sequence":"additional","affiliation":[{"name":"General Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances S","family":"Mair","sequence":"additional","affiliation":[{"name":"General Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhautesh D","family":"Jani","sequence":"additional","affiliation":[{"name":"General Practice and Primary Care, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"bibr1-26335565211056136","volume-title":"The Changing Landscape in Cancer Care","author":"Cancer Research UK","year":"2018"},{"key":"bibr2-26335565211056136","unstructured":"NHS England. 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