{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T19:57:50Z","timestamp":1793563070291,"version":"4.5.0"},"reference-count":68,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Danish Health Authority"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Multimorbidity and Comorbidity"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To categorize and examine the effectiveness regarding health-related quality of life (HRQoL), mental health, and mortality of care models for persons with multimorbidity in primary care, community care, and hospitals through a systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials up to May 2020. One author screened titles and abstracts, and to validate, a second author screened 5% of the studies. Two authors independently extracted data and assessed risk of bias using the tool by the Cochrane Effective Practice and Organisation of Care group. Study inclusion criteria were (1) participants aged \u2265 18\u00a0years with multimorbidity; (2) referred to multimorbidity or two or more specific chronic conditions in the title or abstract; (3) randomized controlled design; and (4) HRQoL, mental health, or mortality as primary outcome measures. We used the Foundation Framework to categorize the models and the PRISMA-guideline for reporting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this study, the first to report effectiveness of care models in patients with multimorbidity in hospital settings, we included 30 studies and 9,777 participants with multimorbidity. 12 studies were located in primary care, 9 in community care, and 9 in hospitals. HRQoL was reported as the primary outcome in 12 studies, mental health in 17 studies, and mortality in three studies\u2014with significant improvements in 5, 14, and 2, respectively. The studies are presented according to settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although 20 of the care models reported positive effects, the variations in populations, settings, model elements, and outcome measures made it difficult to conclude on which models and model elements were effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26335565221134017","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T21:03:49Z","timestamp":1666904629000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Models of care for improving health-related quality of life, mental health, or mortality in persons with multimorbidity: A systematic review of randomized controlled trials"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7163-5703","authenticated-orcid":false,"given":"Christian U","family":"Eriksen","sequence":"first","affiliation":[{"name":"Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6123-8309","authenticated-orcid":false,"given":"Nina","family":"Kamstrup\u2013Larsen","sequence":"additional","affiliation":[{"name":"The Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; AND Innovation and Research Center for Multimorbidity, Slagelse Hospital, Region Zealand, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-2170","authenticated-orcid":false,"given":"Hanne","family":"Birke","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie A L","family":"Helding","sequence":"additional","affiliation":[{"name":"Rigshospitalet and DanTrials ApS, Juliane Marie Centre, Kobenhavn, Denmark; Zero Phase 1 Unit, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Ghith","sequence":"additional","affiliation":[{"name":"Research Group for Genomic Epidemiology, National Food Institute, Technical University of Denmark, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S","family":"Andersen","sequence":"additional","affiliation":[{"name":"The Research Unit for General Practice, Department of Public Health, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fr\u00f8lich","sequence":"additional","affiliation":[{"name":"The Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; AND Innovation and Research Center for Multimorbidity, Slagelse Hospital, Region Zealand, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"bibr1-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1337"},{"key":"bibr2-26335565221134017","volume-title":"Multimorbidity: technical series on safer primary care","author":"World Health Organization","year":"2016"},{"key":"bibr3-26335565221134017","doi-asserted-by":"publisher","DOI":"10.3109\/13814789609162146"},{"key":"bibr4-26335565221134017","doi-asserted-by":"publisher","DOI":"10.3109\/02813432.2016.1153242"},{"key":"bibr5-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00107-9"},{"key":"bibr6-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1007\/bf03391611"},{"key":"bibr7-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1733-2"},{"key":"bibr8-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160264"},{"key":"bibr9-26335565221134017","first-page":"1","volume":"100","author":"Freid VM","year":"2012","journal-title":"NCHS Data Brief"},{"key":"bibr10-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-017-0346-6"},{"key":"bibr11-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4314-8"},{"key":"bibr12-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214183"},{"key":"bibr13-26335565221134017","doi-asserted-by":"publisher","DOI":"10.15256\/joc.2017.7.97"},{"key":"bibr14-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.15.1909"},{"key":"bibr15-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1775"},{"key":"bibr16-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2017.06.002"},{"key":"bibr17-26335565221134017","volume-title":"Framework on integrated people-centred health services","author":"World Health Organization","year":"2016"},{"key":"bibr18-26335565221134017","volume-title":"Multimorbidity care model: Recommendations from the consensus meeting of the Joint action on chronic","author":"CHRODIS","year":"2016"},{"key":"bibr19-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2150"},{"key":"bibr20-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006560.pub2"},{"key":"bibr21-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006560.pub3"},{"key":"bibr22-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006560.pub4"},{"key":"bibr23-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01817-z"},{"key":"bibr24-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"bibr25-26335565221134017","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31308-4"},{"key":"bibr26-26335565221134017","unstructured":"pubmed.gov. 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